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作者

Hongbin Zhang Ke Xu Qin Xiang Lijuan Zhao Benxu Tan Ping Ju Xiufu Lan Yi Liu Jian Zhang Zheng Fu Chao Li Jinzhi Wang Jixiang Song Yun Xiao Zhaobo Cheng Yan Wang Shu Zhang Tingxiu Xiang

作者单位

Corresponding author. Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China Department of Oncology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610599, PR China Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China Department of Oncology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402177, PR China Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China College of Science and Mathematics, West Chester University of Pennsylvania, West Chester, PA 19383, USA Department of Orthopedics, Daping Hospital, Army Medical University, Chongqing 400042, PR China Engineering Department, Women & Children's Health Care Hospital of Linyi, Linyi, Shandong 276016, PR China Department of Oncology, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250013, PR China Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong 250013, PR China Department of Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong 250117, PR China Department of Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong 250117, PR China Medical Department, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong 250013, PR China Department of Oncology, Chongqing Traditional Chinese Medicine Hospital, Chongqing 400042, PR China Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China Department of Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong 250117, PR China Department of Oncology, People's Hospital of Juxian County, Rizhao, Shandong 276599, PR China Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, PR China Corresponding author. Department of Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong 250117, PR China

刊名

Genes and Diseases

年份

2022

卷号

Vol.9 No.1

页码

151-164

ISSN

2352-3042

关键词

CDK1 HCC LPCAT1 Overall survival Prognostic marker

摘要

This study aimed to investigate the relationships between LPCAT1 expression and clinicopathologic parameters of hepatocellular carcinoma , further, to explore the effect of LPCAT1 on overall survival in patients with HCC, and its possible mechanism. Bioinformatics analysis using high throughput RNA-sequencing data from TCGA was utilized to explore the differential expression of LPCAT1 between normal and tumor tissues, and the associations between LPCAT1 expression and clinicopathological parame...更多

This study aimed to investigate the relationships between LPCAT1 expression and clinicopathologic parameters of hepatocellular carcinoma , further, to explore the effect of LPCAT1 on overall survival in patients with HCC, and its possible mechanism. Bioinformatics analysis using high throughput RNA-sequencing data from TCGA was utilized to explore the differential expression of LPCAT1 between normal and tumor tissues, and the associations between LPCAT1 expression and clinicopathological parameters. Survival analyses and subgroup survival analyses were utilized to elucidate the effect of LPCAT1 on OS in patients with HCC. Univariate analysis and multivariate analysis were used to investigate the prognostic factors. Potential LPCAT1 related tumor genes were identified by the methodology of differentially expressed genes screening. GO term enrichment analysis, KEGG pathway analysis and the PPI network were used to explore the potential mechanism. LPCAT1 was significantly overexpressed in HCC tumor tissues compared with normal tissues. The LPCAT1 expression was related to tumor grade, ECOG score, AFP and TNM stage, with P values of 0.000, 0.000, 0.007 and 0.000, respectively. Multivariate analysis demonstrated that LPCAT1 expression was independently associated with OS, with an HR of 1.04 . The KEGG pathway enrichment analyses showed that overlapped DEGs mainly participate in the cell cycle. Finally, we identified a hub gene, CDK1, which has been reported to act on the cell cycle, consistent with the result of KEGG enrichment analysis. Collectively, these data confirmed LPCAT1 was upregulated in HCC, and was an independent predictor of the prognosis.收起

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