Department of Hepatobiliary Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, ChinaSchool of Medicine, Shandong University, Jinan, 250012, China
刊名
Chinese Journal of Cancer Prevention and Treatment
年份
2021
卷号
Vol.28 No.13
页码
1033
ISSN
1673-5269
摘要
Objective: To analyze the epidemiological characteristics of CRC and the influencing factors of synchronous colorectal liver metastasis in colorectal cancer, so as to provide better guidance and basis for the prevention, diagnosis, treatment and prognosis of CRC. Methods: Using 'colorectal neoplasms, liver metastases, synchronous, epidemiology, risk factors' as the English key words, we searched for relevant literatures published in PubMed, CNKI and Wanfang database from 1999-01-01 to 2020-06-3...更多
Objective: To analyze the epidemiological characteristics of CRC and the influencing factors of synchronous colorectal liver metastasis in colorectal cancer, so as to provide better guidance and basis for the prevention, diagnosis, treatment and prognosis of CRC. Methods: Using 'colorectal neoplasms, liver metastases, synchronous, epidemiology, risk factors' as the English key words, we searched for relevant literatures published in PubMed, CNKI and Wanfang database from 1999-01-01 to 2020-06-31. Inclusion criteria: Epidemiological characteristics of colorectal cancer; the factors contribute to colorectal cancer occurrence; the factors contribute to synchronous colorectal liver metastasis; case-control study of colorectal cancer. A total of 68 articles were analyzed according to the inclusion criteria. Results: In 2018, the number of new cases of CRC in the world exceeded 1.8 million and the number of deaths was about 881 000.Among all kinds of cancers, the global incidence of CRC ranks the third and the mortality ranks the second .However, it is worth noting that the incidence of CRC in the United States has gradually declined, while the incidence and mortality of CRC in China have been kept at a very low level for a long time, but have increased rapidly in recent years. In recent years, the rising trend of the incidence of colon cancer is obviously faster than that of rectal cancer.Colon cancer accounts for an increasing proportion in CRC.In some areas, the incidence of colon cancer has exceeded the incidence of rectal cancer, and shows a near-end trend.The incidence rate of CRC in the highest risk areas globally is 7 times higher than that in the lowest risk areas. Similarly, its incidence in remote and backward areas, like the northwest area in China, is significantly lower than that in eastern coastal cities which have higher economic level. The prevalence rate of CRC increases with the increase of age, showing an aging trend, in which colon cancer is more significant, and the elderly has become the hardest hit population of CRC. The average age of onset of CRC in China has gradually shifted more significantly with the passage of time. Overall, the incidence of CRC in males in both the world and China is significantly higher than that in females.Distant metastasis of CRC is the main cause of poor prognosis and high mortality, and the liver is often the only organ involved.There are many factors affecting the occurrence and liver metastasis of CRC. China is not only a big country of HBV infection, but also a big country of fatty liver disease. China's rich alcohol culture also leads to a large number of drinkers, so the study of CRC needs to be combined with the special situation of non-neoplastic chronic liver disease in China. Conclusions: Colorectal cancer has its characteristics in many aspects, such as age, sex, lesion location, regional distribution and so on.Chronic hepatitis B, alcoholic liver disease and non-alcoholic fatty liver disease also affect liver metastasis of colorectal cancer. The study of colorectal cancer and liver metastasis of colorectal cancer needs to be combined with the special situation of chronic liver disease in China.收起
