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作者

Decheng Wang Mingxin Li Chaochao Xiong Yi Yan Juefu Hu Mengchan Hao Bilin Liang Jing Chen Guang Chen Guoxiang Yang Yong Li Jun Zhang Marina Gulyaeva Alexander Shestopalov Weifeng Shi Yuhai Bi Haizhou Liu Hanzhong Wang Di Liu Jianjun Chen

作者单位

CAS Key Laboratory of Special Pathogens and Biosafety，Wuhan Institute of Virology，Center for Biosafety Mega-Science，Chinese Academy of Sciences，Wuhan 430071，China；National Virus Resource Center，Chinese Academy of Sciences，Wuhan Institute of Virology，Center for Biosafety Mega-Science，Wuhan 430071，China；University of Chinese Academy of Sciences，Beijing 100049，China；CAS Key Laboratory of Special Pathogens and Biosafety，Wuhan Institute of Virology，Center for Biosafety Mega-Science，Chinese Academy of Sciences，Wuhan 430071，China；University of Chinese Academy of Sciences，Beijing 100049，China；CAS Key Laboratory of Special Pathogens and Biosafety，Wuhan Institute of Virology，Center for Biosafety Mega-Science，Chinese Academy of Sciences，Wuhan 430071，China；National Virus Resource Center，Chinese Academy of Sciences，Wuhan Institute of Virology，Center for Biosafety Mega-Science，Wuhan 430071，China；Hubei Wildlife Rescue，Research and Development Center，Wuhan 430074，China；Novosibirsk State University，Novosibirsk 630090，Russia；Federal Research Center of Fundamental and Translational Medicine，Novosibirsk 630117，Russia；Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong，Shandong First Medical University & Shandong Academy of Medical Sciences，Taian 271000，China；CAS，Key Laboratory of Pathogenic Microbiology and Immunology，Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease，Institute of Microbiology，Chinese Academy of Sciences，Beijing 100101，China；Center for Influenza Research and Early Warning (CASCIRE)，Chinese Academy of Sciences，Beijing 100101，China；CAS Key Laboratory of Special Pathogens and Biosafety，Wuhan Institute of Virology，Center for Biosafety Mega-Science，Chinese Academy of Sciences，Wuhan 430071，China；CAS Key Laboratory of Special Pathogens and Biosafety，Wuhan Institute of Virology，Center for Biosafety Mega-Science，Chinese Academy of Sciences，Wuhan 430071，China；National Virus Resource Center，Chinese Academy of Sciences，Wuhan Institute of Virology，Center for Biosafety Mega-Science，Wuhan 430071，China；University of Chinese Academy of Sciences，Beijing 100049，China；Center for Influenza Research and Early Warning (CASCIRE)，Chinese Academy of Sciences，Beijing 100101，China

刊名

科学通报(英文版)

年份

2021

卷号

第66卷

期号

第19期

页码

2014-2024

ISSN

0023-074X

关键词

Avian influenza viruses Migratory birds Yangtze River wetlands

摘要

Migratory birds are considered natural reservoirs of avian influenza A viruses .To further our viral ecology knowledge and understand the subsequent risk posed by wild birds,we conducted a 4-year surveillance study of AIVs in the bird wintering wetlands of the Yangtze River,China.We collected over 8000 samples and isolated 122 AIV strains.Analyses were then carried out with 108 novel sequenced genomes and data were deposited in GISAID and other public databases.The results showed that the Yangtz...更多

Migratory birds are considered natural reservoirs of avian influenza A viruses .To further our viral ecology knowledge and understand the subsequent risk posed by wild birds,we conducted a 4-year surveillance study of AIVs in the bird wintering wetlands of the Yangtze River,China.We collected over 8000 samples and isolated 122 AIV strains.Analyses were then carried out with 108 novel sequenced genomes and data were deposited in GISAID and other public databases.The results showed that the Yangtze River wintering wetlands functioned as a mixing ground,where various subtypes of AIVs were detected harboring a high diversity of nucleotide sequences;moreover,a portion of AIV gene segments were persistent inter-seasonally.Phylogenetic incongruence presented complex reassortment events and distinct patterns among various subtypes.In addition,we observed that viral gene segments in win-tering wetlands were closely related to known North American isolates,indicating that intercontinental gene flow occurred.Notably,highly pathogenic H5 and low pathogenic H9 viruses,which usually circu-late in poultry,were found to have crossed the poultry/wild bird interface,with the viruses introduced to wintering birds.Overall,this study represented the largest AIV surveillance effort of wild birds within the Yangtze River wintering wetlands.Surveillance data highlighted the important role of wintering wild birds in the ecology of AIVs and may enable future early warnings of novel AIV emergence收起

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期刊

浏览量

21