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作者

Wang, Xiaoyun Zheng, Yongqing Jin, Lina Zhu, Xiuying Sun, Yongle

作者单位

Department of Nursing, Yucheng People’s Hospital, Development Road 753, Shandong Province, Yucheng City, Dezhou City, 251200, China Department of Hematology, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250000, China Department of Hematology, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan, 250000, China Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwuqi Road, Huaiyin District, Shandong Province, Jinan City, 250021, China Department of Hematology, Binzhou People’s Hospital, Shandong Province, Binzhou, 256610, China Department of Hematology, Jinan Central Hospital, No. 105 Jie Fang Road, Shandong Province, Jinan City, 250000, China

刊名

Latin American Journal of Pharmacy

年份

2021

卷号

Vol.40 No.9

页码

2137

ISSN

0326-2383

摘要

Doxorubicin is an effective anti-neoplastic mediator; however, the usage is limited ow-ing to its cardiomyopathy. Betanin is an active radical scavenger widely used in the regulation of cere-brovascular blood supply. The present work was focused on investigating the effect of betanin in rats with cardiomyopathy induced by DOX. Cardiotoxicity was induced by IP injection of DOX for two weeks in the rat. DOX treated rats showed an increase in lipid peroxidation and decreased antioxidants status...更多

Doxorubicin is an effective anti-neoplastic mediator; however, the usage is limited ow-ing to its cardiomyopathy. Betanin is an active radical scavenger widely used in the regulation of cere-brovascular blood supply. The present work was focused on investigating the effect of betanin in rats with cardiomyopathy induced by DOX. Cardiotoxicity was induced by IP injection of DOX for two weeks in the rat. DOX treated rats showed an increase in lipid peroxidation and decreased antioxidants status . We observed irregular patho-logical structures in DOX-induced rats. The DOX treatment significant increase the myocardium biomarkers such as Ct-I, BNP, CK-MB in serum. Significantly enhanced activity of pro-inflammatory cy-tokines in DOX treated rats. Betanin treated rats show increased antioxidants, reduced cardiac damage biomarkers, and suppressed inflammatory cytokines in DOX-induced rats. Furthermore, a DOX-induced rat shows increased PTEN, PI3K, and decreased p-AKT, thereby enhancing pro-apoptotic protein Bax, Bad, Caspase 3 expression resulting in induced cell apoptosis. Whereas betanin treatment significantly down in the activation PTEN/AKT and pro-apoptotic protein, enhance Bcl-2 expression in DOX-mediated rats. The overall finding shows that betanin inhibits inflammation and cell apoptosis by modulating PTEN/AKT signaling in the DOX-induced rat.收起

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