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作者

Liu, Wei Zhang, Shuping Nekhaǐ, Sergei Yu Liu, Sijin

作者单位

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China Shandong Academy of Medical Sciences, Jinan, 250062, China University of Chinese Academy of Sciences, Beijing, 100049, China Center for Sickle Cell Disease and Department of Medicine, College of Medicine, Howard University, Washington, 20059, DC, United States University Creative Research Initiatives Center, Shandong First Medical University & Department of Hematology, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250062, China Shandong Medicinal Biotechnology Center, Jinan, 250062, China

刊名

Current Clinical Microbiology Reports

年份

2020

卷号

Vol.7 No.2

页码

13

ISSN

2196-5471

摘要

Purpose of the review: The ongoing outbreak of novel coronavirus pneumonia caused by the 2019 novel coronavirus in China is lifting widespread concerns. Thus, therapeutic options are urgently needed, and will be discussed in this review. Recent findings: Iron-containing enzymes are required for viruses most likely including coronaviruses to complete their replication process. Moreover, poor prognosis occurred in the conditions of iron overload for patients upon infections of viruses. Thus, li...更多

Purpose of the review: The ongoing outbreak of novel coronavirus pneumonia caused by the 2019 novel coronavirus in China is lifting widespread concerns. Thus, therapeutic options are urgently needed, and will be discussed in this review. Recent findings: Iron-containing enzymes are required for viruses most likely including coronaviruses to complete their replication process. Moreover, poor prognosis occurred in the conditions of iron overload for patients upon infections of viruses. Thus, limiting iron represents a promising adjuvant strategy in treating viral infection through oral uptake or venous injection of iron chelators, or through the manipulation of the key iron regulators. For example, treatment with iron chelator deferiprone has been shown to prolong the survival of acquired immunodeficiency syndrome patients. Increasing intracellular iron efflux via increasing iron exporter ferroportin expression also exhibits antiviral effect on human immunodeficiency virus . The implications of other metals besides iron are also briefly discussed. Summary: For even though we know little about iron regulation in COVID-19 patients thus far, it could be deduced from other viral infections that iron chelation might be an alternative beneficial adjuvant in treating COVID-19.收起

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