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作者

Shi, Xingyue Chen, Chong Liu, Fenglin Lyu, Di Xu, Jie Han, Zhengxiang

作者单位

Department of Breast Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221006, China Department of Oncology, Traditional Chinese Medicine Hospital of Xuzhou City, Xuzhou, 221003, China Department of Hematology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221006, China Department of Oncology, The Second Affiliated Hospital of Shandong First Medical University, Taian, 271000, China Department of Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221006, China

刊名

Cancer Research on Prevention and Treatment

年份

2020

卷号

Vol.47 No.7

页码

531

ISSN

1000-8578

摘要

Objective To investigate Neuropilin-1 expression in Treg and PDC cells in peripheral blood of non-small cell lung cancer patients and clinical significance. Methods We collected the peripheral blood of 49 diagnosed non-small cell lung cancer patients, and 33 healthy subjects were taken as control group. The expression of NRP-1 on Treg and PDC cells in peripheral blood were detected by flow cytometry. Results The expression rate of NRP-1 in Treg cells of NSCLC patients was significantly higher th...更多

Objective To investigate Neuropilin-1 expression in Treg and PDC cells in peripheral blood of non-small cell lung cancer patients and clinical significance. Methods We collected the peripheral blood of 49 diagnosed non-small cell lung cancer patients, and 33 healthy subjects were taken as control group. The expression of NRP-1 on Treg and PDC cells in peripheral blood were detected by flow cytometry. Results The expression rate of NRP-1 in Treg cells of NSCLC patients was significantly higher than that of healthy subjects . The expression of NRP-1 in Treg cells of NSCLC patients was correlated with the maximum diameter of tumor, lymph node metastasis, TNM stage and differentiation degree ; the expression of PDC was related to the maximum diameter of the tumor, lymph node metastasis and TNM staging. Conclusion The expression of NRP-1 in peripheral blood Treg and PDC cells may be associated with immunoregulation of non-small cell lung cancer. It may be a tumor marker for predicting the prognosis of NSCLC patients, and a new target for lung cancer treatment.收起

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