Aerobic redox deracemization of α-aryl glycine esters

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作者: Chen, Xiaohan Yan, Lei Zhang, Lu Zhao, Changyin Feng, Guidong Chen, Lei Sun, Shutao Liu, Qingyun Liu, Lei

作者单位: Department of Internal Medicine, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, China College of Chemical and Biological Engineering, State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology, Shandong University of Science and Technology, Qingdao, 266590, China School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China

摘要: An effective redox deracemization of α-aryl glycine esters has been described. The one-pot redox process consisted of copper catalysis using molecular oxygen as terminal oxidant and chiral phosphoric acid catalyzed asymmetric transfer hydrogenation with benzothiazoline as hydride donor. The reaction exhibited good functional group tolerance, providing a range of optically active non-natural α-aryl glycine esters with excellent enantioselectivity.

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