Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, ChinaDepartment of Radiation Oncology, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, 100071, ChinaWeifang Medical University, Weifang, Shandong, 261053, ChinaDepartment of Oncology, Renmin Hospital of Wuhan University, Wuhan, 430060, China
刊名
Cancer Cell International
年份
2019
卷号
Vol.19 No.1
ISSN
1475-2867
摘要
Background: Considering the effect of smoking on tumor immunity, we attempted to investigate the impact of smoking history on the prognostic value of circulating naïve and memory CD4+ and CD8+ T cells in advanced non-small cell lung cancer treated with chemotherapy. Methods: Of 196 histologically confirmed advanced NSCLC, 98 eligible ones were enrolled. Naïve and memory CD4+ and CD8+ T cells from peripheral blood were measured by flow cytometry. Kaplan-Meier curves helped estimate patients' sur...更多
Background: Considering the effect of smoking on tumor immunity, we attempted to investigate the impact of smoking history on the prognostic value of circulating naïve and memory CD4+ and CD8+ T cells in advanced non-small cell lung cancer treated with chemotherapy. Methods: Of 196 histologically confirmed advanced NSCLC, 98 eligible ones were enrolled. Naïve and memory CD4+ and CD8+ T cells from peripheral blood were measured by flow cytometry. Kaplan-Meier curves helped estimate patients' survival. The uni- and multivariate Cox proportional hazards regression model was employed in the assessment of the prognostic value of factors. Results: Multivariate survival analyses showed that peripheral naïve CD4+ T cells independently predicted favorable overall survival in ever smokers with advanced NSCLC , but unfavorable OS in never smokers with the same ailment . Ever smokers presented a different distribution of naïve and memory T cells: low expression levels of naïve CD4+ T , naïve CD8+ T , CD4+ naïve/memory ratio , and CD8+ naïve/memory ratio , and high distributions of memory CD4 + T , memory CD8 + T , and naïve CD8/CD4 ratio , when compared to never smokers. Conclusions: We revealed the impact of cigarette-smoking on peripheral naïve CD4+ T cells' prognostic value in advanced NSCLC patients. These results could help in refining personalized treatment for advanced NSCLC patients.收起
