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作者

Fan-Jie Liu, Hong-Hao Xu, Ying Yin, Yuan-Zhen Chen, Liang-Yu Xie, Hua-Zhong Li, Dan-Dan Wang, Bin Shi

作者单位

Bone Biomechanics Engineering Laboratory of Shandong Province, Shandong Medicinal Biotechnology Center (School of Biomedical Sciences), Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250062 Shandong Province, China. Department of Acupuncture, The Affiliated Hospital of Shandong University of TCM, Jinan, 250014 Shandong Province, China. Affiliations Department of Trauma Bone Surgery, The Affiliated Hospital of Shandong University of TCM, Jinan, 250014 Shandong Province, China.

刊名

Disease markers

年份

2022

卷号

Vol.2022

页码

5389162

ISSN

1875-8630

摘要

Objective: Spinal cord injury has become popular in recent years, and cognitive decline is a common complication. Adiponectin is a common protein hormone involved in the course of many diseases, but its relationship with SCI has not yet been elucidated. The purpose of our prospective study is to explore whether adiponectin can be used as a biomarker of cognitive decline in SCI. Methods: A total of 64 healthy volunteers and 92 patients with acute SCI were recruited by us. Serum adiponectin level...更多

Objective: Spinal cord injury has become popular in recent years, and cognitive decline is a common complication. Adiponectin is a common protein hormone involved in the course of many diseases, but its relationship with SCI has not yet been elucidated. The purpose of our prospective study is to explore whether adiponectin can be used as a biomarker of cognitive decline in SCI. Methods: A total of 64 healthy volunteers and 92 patients with acute SCI were recruited by us. Serum adiponectin levels, demographic data , lifestyle , medical history , and clinical baseline data were recorded. Three months after enrollment, we used the Montreal Cognitive Assessment to evaluate cognitive function. Based on a quarter of the serum adiponectin levels, SCI patients were divided into 4 groups, and the differences in their MoCA scores were compared. In addition, we used multivariate linear regression to predict the risk factors of the MoCA score. Results: The serum adiponectin level of SCI patients was significantly lower than that of the healthy control group , and there was a significant difference between the two . The group with higher serum adiponectin levels after 3 months of spinal cord injury had higher MoCA scores. Multivariate regression analysis showed that serum adiponectin level is a protective factor for cognitive function after SCI . Conclusions: Serum adiponectin levels can be used as an independent predictor of cognitive function in patients with acute SCI.收起

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