A Smart Drug Delivery System Based on Thermo-Responsive Polymer Gated Au NRs@SiO Nano-Platform

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作者单位: Affiliations: 1: Women’s Hospital, Zhejiang University School of Medicine, Medical Engineering Office, Zhejiang, Hangzhou, 310006, China 2: Shandong First Medical University (Shandong Academy of Medical Sciences), clinical Medicine Major, Shandong, Jinan, 250000, China 3: College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China

摘要: A key challenge for nanoparticles-based drug delivery system is to achieve manageable drug release in tumour cell. In this study, a versatile system combining photothermal therapy and controllable drug release for tumour cells using temperature-sensitive block copolymer coupled Au [email protected] 2 is reported. While the Au NRs serve as hyperthermal agent and the mesoporous silica was used to improve the drug loading and decrease biotoxicity. The block copolymer acted as “gatekeeper” to regu...更多; A key challenge for nanoparticles-based drug delivery system is to achieve manageable drug release in tumour cell. In this study, a versatile system combining photothermal therapy and controllable drug release for tumour cells using temperature-sensitive block copolymer coupled Au [email protected] 2 is reported. While the Au NRs serve as hyperthermal agent and the mesoporous silica was used to improve the drug loading and decrease biotoxicity. The block copolymer acted as “gatekeeper” to regulate the release of model drug . Through in vivo and in vitro experiments, we achieved the truly controllable drug release and photothermal therapy with the collaborative effect of the three constituents of the nanocomposites. The reported nanocomposites pave the way to high-performance controllable drug release and photothermal therapy system.收起

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