获取途径

作者

Dr. Wanjun Gong, Dr. Lingdong Jiang, Yanxia Zhu, Mengna Jiang, Dr. Danyang Chen, Zhaokui Jin, Prof. Shucun Qin, Prof. Zhiqiang Yu, Prof. Qianjun He

作者单位

School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515 Guangdong, China Marshall Laboratory of Biomedical Engineering, School of Biomedical Engineering, Health Science Center, Shenzhen University, No. 1066 Xueyuan Avenue, Shenzhen, 518060 Guangdong, China Center of Hydrogen Science, Shanghai Jiao Tong University, Shanghai, 200240 China Institute of Atherosclerosis, Taishan Institute for Hydrogen Biological Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, 271000 Shandong, China

刊名

Angewandte Chemie

页码

e202114594

ISSN

0044-8249

关键词

Fluorescence imaging Hydrogen medicine Mesoporous silica nanoparticles Molecular imaging probe

摘要

To reveal the biomedical effects and mechanisms of hydrogen molecules urgently needs hydrogen molecular imaging probes as an imperative tool, but the development of these probes is extremely challenging. A catalytic hydrogenation strategy is proposed to design and synthesize a ratiometric fluorescent probe by encapsulating Pd nanoparticles and conjugating azido-/coumarin-modified fluorophore into mesoporous silica nanoparticles, realizing in vitro and in vivo fluorescence imaging of hydrogen mol...更多

To reveal the biomedical effects and mechanisms of hydrogen molecules urgently needs hydrogen molecular imaging probes as an imperative tool, but the development of these probes is extremely challenging. A catalytic hydrogenation strategy is proposed to design and synthesize a ratiometric fluorescent probe by encapsulating Pd nanoparticles and conjugating azido-/coumarin-modified fluorophore into mesoporous silica nanoparticles, realizing in vitro and in vivo fluorescence imaging of hydrogen molecules. The developed hydrogen probe exhibits high sensitivity, rapid responsivity, high selectivity and low detection limit, enabling rapid and real-time detection of hydrogen molecules both in cells and in the body of animal and plant. By application of the developed fluorescent probe, we have directly observed the super-high transmembrane and ultrafast transport abilities of hydrogen molecules in cells, animals and plants, and discovered in vivo high diffusion of hydrogen molecules.收起

文献类型

期刊

浏览量

19