An intersegmental single-cell profile reveals aortic heterogeneity and identifies a novel Malat1+vascular smooth muscle subtype involved in abdominal aortic aneurysm formation

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作者: Liwen Yu Jie Zhang Amy Gao Meng Zhang Zunzhe Wang Fangpu Yu Xiaobin Guo Guohai Su Yun Zhang Cheng Zhang

作者单位: The Key Laboratory of Cardiovascular Remodeling and Function Research；Cardiovascular Disease Research Center of Shandong First Medical University

摘要: The developmental origin,anatomical location,and other factors contribute to aortic heterogeneity in a physiological state.On this basis,vascular diseases occur at different ratios based on position specificity,even with the same risk factor.However,the continuous intersegmental aortic profile has been rarely reported at the single-cell level.To reveal aortic heterogeneity,we identified 15 cell subtypes from five continuous aortic segments by marker genes and functional definitions.

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