Affiliations 1 Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 250021 Jinan, Shandong, PR China. 2 Department of Neurology, Shandong Provincial Hospital, Shandong University, 250021 Jinan, Shandong, PR China. 3 Department of Neurobiology, Care Sciences and Society, Aging Research Center and Center for Alzheimer Research, Karolinska Institutet-Stockholm University, 17177 Stockholm, Sweden.
The kidney and brain expressed protein rs17070145 polymorphism is associated with both structure and activation of the olfactory cortex. However, no studies have thus far examined whether KIBRA can be linked with olfactory function and whether brain structure plays any role in the association. We addressed these questions in a population-based cross-sectional study among rural-dwelling older adults. This study included 1087 participants derived from the Multidomain Interventions to Delay Dement...更多
The kidney and brain expressed protein rs17070145 polymorphism is associated with both structure and activation of the olfactory cortex. However, no studies have thus far examined whether KIBRA can be linked with olfactory function and whether brain structure plays any role in the association. We addressed these questions in a population-based cross-sectional study among rural-dwelling older adults. This study included 1087 participants derived from the Multidomain Interventions to Delay Dementia and Disability in Rural China, who underwent the brain MRI scans in August 2018 to October 2020; of these, 1016 took the 16-item Sniffin' Sticks identification test and 634 were defined with olfactory impairment . Data were analyzed using the voxel-based morphometry analysis and general linear, logistic, and structural equation models. The KIBRA rs17070145 C-allele was significantly associated with greater gray matter volume mainly in the bilateral orbitofrontal cortex and left thalamus and with the multi-adjusted odds ratio of 0.73 for OI. The left thalamic GMV could mediate 8.08% of the KIBRA-olfaction association . These data suggest that the KIBRA rs17070145 C-allele is associated with a reduced likelihood of OI among older adults, partly mediated through left thalamic GMV.收起
发文期刊《Thalamic gray matter volume mediates the association between KIBRA polymorphism and olfactory function among older adults: a population-based study》历年引证文献趋势图
