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作者

Jingzhe Shang Chunfeng Li Zhujia Jin Shulong Zu Songjie Chen Junlan Chen Ziyi Chen Hua Tang Cheng-Feng Qin Qing Ye Aiping Wu

作者单位

⁸Institute of Immunology, Shandong First Medical University, Tai’an, China ⁴Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA, United States ⁷State Key Laboratory Breeding Base of Basic Science of Stomatology, Ministry of Education, Hospital of Stomatology, Faculty of Medical Sciences, Wuhan University, Wuhan, China ¹Institute of Systems Medicine, Chinese Academy of Medical Sciences & ⁵Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Peking Union Medical College, Beijing, China ⁶Departments of Genetics, School of Medicine, Stanford University, Stanford, CA, United States ³State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China ²Suzhou Institute of Systems Medicine, Suzhou, China

刊名

Frontiers in Cellular and Infection Microbiology

年份

2022

卷号

Vol.12

关键词

immune profiles ZIKV variable pathogenicity transcriptome multi-organization

摘要

The Zika virus is responsible for neurological diseases such as microcephaly, Guillain-Barré syndrome, neuropathy, and myelitis in human adults and children. Previous studies have shown that the Zika virus can infect nerve progenitor cells and interfere with neural development. However, it is unclear how the immune system responds to infection with Zika viruses with variable pathogenicity. Here, we used two Zika strains with relatively different pathogenicity, the Asian ancestral strain CAM/2010...更多

The Zika virus is responsible for neurological diseases such as microcephaly, Guillain-Barré syndrome, neuropathy, and myelitis in human adults and children. Previous studies have shown that the Zika virus can infect nerve progenitor cells and interfere with neural development. However, it is unclear how the immune system responds to infection with Zika viruses with variable pathogenicity. Here, we used two Zika strains with relatively different pathogenicity, the Asian ancestral strain CAM/2010 and the America pandemic strain GZ01/2016, to infect the brains of mice. We found that both strains elicited a strong immune response. Notably, the strain with relatively high pathogenicity, GZ01/2016, caused more intense immune regulation, with stronger CD8+ T cell and macrophage activation at 14 days post infection , as well as a greater immune gene disturbance. Notably, several TNF family genes were upregulated at 14 dpi, including Tnfrsf9, Tnfsf13, Tnfrsf8, Cd40, and Tnfsf10. It was notable that GZ01/2016 could maintain the survival of nerve cells at 7dpi but caused neurological disorders at 14dpi. These results indicate that Zika viruses with high pathogenicity may induce sustained activation of the immune system leading to nerve tissue damage.收起

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