Role of high mobility group box protein 1 in depression: A mechanistic and therapeutic perspective

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作者单位: Affiliations ¹ Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China. ² Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, China. ³ Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China. ⁴ Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China. wmzwlq@16 com.

关键词: Depression High mobility group box 1 Mechanism Neuroinflammation Perspective Review.

摘要: As a common and serious psychiatric disorder, depression significantly affects psychosocial functioning and quality of life. However, the mechanism of depression is still enigmatic and perplexing, which limits its precise and effective therapeutic methods. Recent studies demonstrated that neuroinflammation activation plays an important role in the pathophysiology of depression. In this respect, high mobility group box 1 may be a possible signaling inducer of neuroinflammation and can be a poten...更多; As a common and serious psychiatric disorder, depression significantly affects psychosocial functioning and quality of life. However, the mechanism of depression is still enigmatic and perplexing, which limits its precise and effective therapeutic methods. Recent studies demonstrated that neuroinflammation activation plays an important role in the pathophysiology of depression. In this respect, high mobility group box 1 may be a possible signaling inducer of neuroinflammation and can be a potential mechanistic and therapeutic target for depression. Herein, we review recent studies on the mechanistic and therapeutic targets of HMGB1 in depression and propose potential perspectives on this topic.收起

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