获取途径

作者

Hongyan Ji, Yonghui Yu, Lei Huang, Yan Kou, Xin Liu, Shina Li, Yongfeng Zhang, Zhongliang Li, Xuemei Sun, Jing Wang, Kun Yang, Liying Zhou, Yao Luo, Guoying Zhao, Zhenying Yang, Xiao Zhang, Xiujie Cui, Jing Li, Ying Wang, Jing Shi, Weibing Chen, Yanying Ma, Peng Zhao, Riming Zhao, Kun Zhou, Binghui Li, Renxia Zhu, Yanling Gao, Zhiyuan Zhou, Huan Li, Jinlan Dou, Haiyan Li, Changliang Zhao, Bingjin Zhang, Xiaokang Wang

作者单位

com. ³ Department of Neonatology, Shandong Provincial Hospital, Shandong University, Shandong Provincial Hospital affiliated to Shandong First Medical University, HuaiYin District, No. 324, Jingwu Road, Jinan, 250021, Shandong, China. alice20402@12 com. ⁴ Department of Neonatology, Shandong Provincial Maternity and Child Health Care Hospital, Jinan, China. ⁵ Department of Neonatology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China. ⁶ Department of Neonatology, Jinan Maternity and Child Health Care Hospital, Jinan, Shandong, China. ⁷ Department of Neonatology, Yantai Yuhuangding Hospital, Yantai, Shandong, China. ⁸ Department of Neonatology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China. ⁹ Department of Neonatology, WeiFang Maternal and Child Health Hospital, Weifang, Shandong, China. ¹⁰ Department of Neonatology, Linyi People's Hospital, Linyi, Shandong, China. ¹¹ Department of Pediatrics, Women and Children's Healthcare Hospital of Linyi, Linyi, Shandong, China. ¹² Department of Pediatrics, Taian City Central Hospital, Taian, Shandong, China. ¹³ Department of Pediatrics, Liaocheng People's Hospital, Liaocheng, Shandong, China. ¹⁴ Department of Pediatrics, Binzhou Medical University Hospital, Binzhou, Shandong, China. ¹⁵ Department of Pediatrics, Taian Maternal and Child Health Care Hospital, Taian, Shandong, China. ¹⁶ Department of Pediatrics, Dongying People's Hospital, Dongying, Shandong, China. ¹⁷ Department of Pediatrics, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, China. ¹⁸ Department of Pediatrics, Jinan Central Hospital, Jinan, Shandong, China. ¹⁹ Department of Pediatrics, The Second People's Hospital of Liaocheng, Liaocheng, Shandong, China. ²⁰ Department of Pediatrics, People's Hospital of Rizhao, Rizhao, Shandong, China. ²¹ Department of Pediatrics, Jinan Second Maternal and Child Health Care Hospital, Shandong, China. ²² Department of Pediatrics, Central People's Hospital of Tengzhou, Tengzhou, Shandong, China. ²³ Department of Pediatrics, Juxian Peoples Hospital, Rizhao, Shandong, China. ²⁴ Department of Pediatrics, Liaocheng Dongchangfu Maternal and Child Health Hospital, Liaochen, Shandong, China. ²⁵ Department of Pediatrics, Zibo Maternal and Child Health Hospital, Zibo, Shandong, China. ²⁶ Department of Pediatrics, Zibo Municipal Hospital, Zibo, Shandong, China. ²⁷ Department of Pediatrics, Dezhou Peoples Hospital, Dezhou, Shandong, China. ²⁸ Department of Pediatrics, Heze Municipal Hospital, Heze, Shandong, China. ²⁹ Department of Pediatrics, Hebei Petro China Central Hospital, Langfang, Hebei, China. ³⁰ Department of Pediatrics, Weifang Yidu Central Hospital, Weifang, Shandong, China. ³¹ Department of Pediatrics, Yantai Yantaishan Hospital, Yantai, Shandong, China. ³² Department of Pediatrics, Baogang Third Hospital of Hongci Group, Baotou, China. ³³ Department of Pediatrics, Shengli Oilfield Central Hospital, Dongying, Shandong, China. ³⁴ Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. Affiliations ¹ Department of Neonatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. ² Department of Neonatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. alice20402@12

刊名

Infectious diseases and therapy

年份

2022

ISSN

2193-8229

关键词

Antimicrobial resistance Early-onset neonatal sepsis Infants Pathogen Premature.

摘要

Introduction: Early onset sepsis remains a potentially fatal newborn condition, especially in very preterm infants. Data on the pathogen distribution and antibiotic susceptibility patterns of EOS among very preterm infants are scarce but essential for the choice of empirical antibiotic administration. We sought to assess the epidemiologic characteristics and antibiotic susceptibility patterns of pathogens causing EOS among a cohort of very preterm infants in China. Methods: This prospective, ob...更多

Introduction: Early onset sepsis remains a potentially fatal newborn condition, especially in very preterm infants. Data on the pathogen distribution and antibiotic susceptibility patterns of EOS among very preterm infants are scarce but essential for the choice of empirical antibiotic administration. We sought to assess the epidemiologic characteristics and antibiotic susceptibility patterns of pathogens causing EOS among a cohort of very preterm infants in China. Methods: This prospective, observational study included a cohort of infants born at a gestational age less than 32 weeks of 32 newborn intensive care units in China between January 1, 2018 and December 31, 2020. EOS was defined by isolation of pathogenic species from blood culture within 72 h of birth. Results: A total of 108 EOS cases were identified among 5865 very preterm infants. Incidence of EOS increased with the decrease of GA and birthweight. Escherichia coli was the most common pathogen, followed by Klebsiella spp. . The distribution and proportion of pathogenic bacteria varied significantly by GA. E. coli and Klebsiella spp. showed high resistance to ampicillin and third-generation cephalosporins, while they showed good susceptibility to carbapenem antibiotics and piperacillin-tazobactam. Conclusion: Our data demonstrated that pathogens causing neonatal EOS showed high rates of resistance to ampicillin and third-generation cephalosporins. This raised questions about the best empirical antibiotic choice for preterm infants suspected of having EOS in low- and middle-income countries .收起

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