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作者

Ping Zhang, Yanyan Wang, Xiaomin Xing, Hu Li, Xiaojing Wang, Hanlin Zhang, Xin Wang, Xiubin Li, Yanju Li, Qian Wang

作者单位

Affiliations ¹ Department of Rehabilitation, The Second Affiliated Hospital of Shandong First Medical University, Taian, 271000, China. ² Taian Traffic Hospital, Taian, 271000, China. ³ Department of Neurology, The Second Affiliated Hospital of Shandong First Medical University, Taian, 271000, China. ⁴ Postdoctoral Workstation, Department of Central Laboratory, The Affiliated Taian City Central Hospital of Qingdao University, Taian 271000, China.

刊名

Computational and mathematical methods in medicine

年份

2022

卷号

Vol.2022

页码

5367753

ISSN

1748-6718

摘要

Acute myocardial infarction is the most severe form of coronary heart disease caused by ischemia and hypoxia. The study is aimed at investigating the role of neuropeptides and the mechanism of electroacupuncture in acute myocardial infarction treatment. Compared with the normal population, a significant increase in substance P was observed in the serum of patients with AMI. PGI2 expression was increased in the SP-treated AMI mouse model, and TXA2 expression was decreased. And PI3K pathway-re...更多

Acute myocardial infarction is the most severe form of coronary heart disease caused by ischemia and hypoxia. The study is aimed at investigating the role of neuropeptides and the mechanism of electroacupuncture in acute myocardial infarction treatment. Compared with the normal population, a significant increase in substance P was observed in the serum of patients with AMI. PGI2 expression was increased in the SP-treated AMI mouse model, and TXA2 expression was decreased. And PI3K pathway-related genes, including Pik3ca, Akt, and Mtor, were upregulated in myocardial tissue of SP-treated AMI patients. Human cardiomyocyte cell lines treated with SP increased mRNA and protein expression of PI3K pathway-related genes . Compared to MI control and EA-treated MI rat models, Myd88, MTOR, Akt1, Sp, and Irak1 were differentially expressed, consistent with in vivo and in vitro studies. EA treatment significantly enriched PI3K/AKT signaling pathway genes within MI-associated differentially expressed genes according to Kyoto Encyclopedia of Genes and Genomes . Furthermore, it was confirmed by molecular docking analysis that PIK3CA, AKT1, and mTOR form stable dockings with neuropeptide SP. PI3K/AKT pathway activity may be affected directly or indirectly by EA via SP, which corrects the PGI2/TXA2 metabolic imbalance in AMI. MI treatment is now better understood as a result of this finding.收起

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