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作者

Wenhao Hao, Huali Meng, Hui Li, Yan Zheng, Chunhong Song, Ziping Jiang, Xue Bai, Zhiyue Zhang, Lei Du, Pei Liu, Hao Wu

作者单位

Affiliations ¹ Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. ² Research Center of Translational Medicine, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250013, China. ³ NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. ⁴ Department of Laboratory Animal Center, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, China. ⁵ Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun 130021, China. ⁶ Department of Physical and Chemical Inspection, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. ⁷ Department of Plastic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

刊名

Nutrients

年份

2022

卷号

Vol.14 No.19

页码

4139

ISSN

2072-6643

关键词

cutaneous diabetes krill oil skin wound healing

摘要

Diabetes mellitus impairs the wound healing process, seriously threatening the health of the diabetic population. To date, few effective approaches have been developed for the treatment of diabetic wounds. Krill oil contains bioactive components that have potent anti-inflammatory and anti-oxidative activities. As prolonged inflammation is a crucial contributor to DM-impaired wound healing, we speculated that the local application of KO would accelerate diabetic wound healing. Therefore, KO was...更多

Diabetes mellitus impairs the wound healing process, seriously threatening the health of the diabetic population. To date, few effective approaches have been developed for the treatment of diabetic wounds. Krill oil contains bioactive components that have potent anti-inflammatory and anti-oxidative activities. As prolonged inflammation is a crucial contributor to DM-impaired wound healing, we speculated that the local application of KO would accelerate diabetic wound healing. Therefore, KO was applied to artificially created wounds of type 2 diabetic mice induced by streptozotocin and high-fat diet. The diabetic mice had a delayed wound healing process compared with the non-diabetic control mice, with excessive inflammation, impaired collagen deposition, and depressed neovascularization in the wound area. These effects were dramatically reversed by KO. In vitro, KO blocked the TNF-α-induced macrophage inflammation, fibroblast dysfunction, and endothelial angiogenic impairment. The present study in mice suggests that KO local application could be a viable approach in the management of diabetic wounds.收起

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