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作者

Jianxiong Wei Shuyang Chang Siyi Liu Lixia Tian Xuan Zhu Shuo Wang Xiaoqiong Zhou Yuying Wang Linping Xu Fu-Quan Huo Lingli Liang

作者单位

¹Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi 710061, China ⁵Department of Anesthesiology, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, China ²Institute of Neuroscience, Translational Medicine Institute, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi 710061, China ⁴Jianxiong Wei and Shuyang Chang contribute to this work equally. ³Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, Shaanxi 710061, China

刊名

Brain Research Bulletin

年份

2022

ISSN

0361-9230

关键词

LSD1 Dorsal root ganglion Radicular pain Neuropathic pain

分类号

616.89

摘要

Low back and radicular pain syndromes, usually caused by local inflammation and irritation to the nerve root and dorsal root ganglion , are common throughout medical practice, but sufficient pain relief is scarce. In this study, we employed a chronic compression of DRG –induced radicular pain model in rats to explore whether lysine-specific demethylase 1 , a histone demethylase and transcriptional co-repressor, is involved in the pathological process of radicular pain. We found that LSD1 was exp...更多

Low back and radicular pain syndromes, usually caused by local inflammation and irritation to the nerve root and dorsal root ganglion , are common throughout medical practice, but sufficient pain relief is scarce. In this study, we employed a chronic compression of DRG –induced radicular pain model in rats to explore whether lysine-specific demethylase 1 , a histone demethylase and transcriptional co-repressor, is involved in the pathological process of radicular pain. We found that LSD1 was expressed in various-sized DRG neurons by immunohistochemistry. CCD induced the upregulation of LSD1 in compressed L–L DRGs. Moreover, either LSD1 small interfering RNAs or LSD1 inhibitor attenuated CCD–induced pain hypersensitivities. LSD1 was also upregulated in the injured lumbar 4 DRG in a spinal nerve ligation –induced neuropathic pain mouse model. Nevertheless, LSD1 was not altered in L–L DRGs in complete Freund’s adjuvant–induced inflammatory pain mouse model, paclitaxel– or streptozotocin–induced neuropathic pain models. Furthermore, knockdown of LSD1 in the injured L DRG reversed SNL–induced pain hypersensitivities in mice. Therefore, we speculate that nerve injury induced the upregulation of LSD1 in the injured DRGs, which contributes to neuropathic pain hypersensitivities; thus, LSD1 may serve as a potential target for the treatment of radicular pain and neuropathic pain.收起

学科

【SCI学科】NEUROSCIENCES 【ESI学科】NEUROSCIENCE & BEHAVIOR

影响因子

2018年:3.103;2017年:3.44;2016年:3.033;2015年:2.572;2014年:2.718

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