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作者

Pu-Yun OuYang, Zhi-Qiao Liu, Qing-Guang Lin, Yun He, Zhi-Xin Guo, Wen-Yan Yao, Sen-Kui Xu, Qing-He Peng, Su-Ming Xiao, Jiajian Li, Anwei Li, Bao-Yu Zhang, Shan-Shan Yang, Wei Fan, Chuan-Miao Xie, Yi-Shan Wu, Xu Zhang, Chun-Yan Chen, Fang-Yun Xie

作者单位

Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, 510060, Guangdong, China. ⁴ CVTE Research, Guangzhou, Guangdong, China. ⁵ Department of Radiation Oncology, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, Shandong, China. ⁶ Department of Nuclear Medicine, Sun Yat-sen University Cancer Center Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, No. 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, China. xiefy@sysucc.org.cn. Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, No. 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, China. ² Department of Ultrasound, Sun Yat-sen University Cancer Center Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong, China. ⁸ Department of Radiation Oncology, Sun Yat-sen University Cancer Center Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, 510060, Guangdong, China. ³ Department of Radiology, Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, 510060, Guangdong, China. ⁷ Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center Collaborative Innovation Center for Cancer Medicine Affiliations ¹ Department of Radiation Oncology, Sun Yat-sen University Cancer Center

刊名

European journal of nuclear medicine and molecular imaging

年份

2022

ISSN

1619-7089

关键词

MRI PET/CT Recurrent nasopharyngeal carcinoma.

摘要

Purpose: To compare PET/CT, MRI and ultrasonography in detecting recurrence of nasopharyngeal carcinoma and identify their benefit in staging, contouring and overall survival . Methods: Cohort A included 1453 patients with or without histopathology-confirmed local recurrence, while cohort B consisted of 316 patients with 606 histopathology-confirmed lymph nodes to compare the sensitivities and specificities of PET/CT, MRI and ultrasonography using McNemar test. Cohorts C and D consisted of 273 p...更多

Purpose: To compare PET/CT, MRI and ultrasonography in detecting recurrence of nasopharyngeal carcinoma and identify their benefit in staging, contouring and overall survival . Methods: Cohort A included 1453 patients with or without histopathology-confirmed local recurrence, while cohort B consisted of 316 patients with 606 histopathology-confirmed lymph nodes to compare the sensitivities and specificities of PET/CT, MRI and ultrasonography using McNemar test. Cohorts C and D consisted of 273 patients from cohort A and 267 patients from cohort B, respectively, to compare the distribution of PET/CT-based and MRI-based rT-stage and rN-stage and the accuracy of rN-stage using McNemar test. Cohort E included 30 random patients from cohort A to evaluate the changes in contouring with or without PET/CT by related-samples T test or Wilcoxon rank test. The OS of 61 rT3-4N0M0 patients staged by PET/CT plus MRI and 67 MRI-staged rT3-4N0M0 patients who underwent similar salvage treatment were compared by log-rank test and Cox regression. Results: PET/CT had similar specificity to MRI but higher sensitivity in detecting local recurrence. PET/CT, MRI and ultrasonography had comparable specificities, but PET/CT had greater sensitivity than MRI and similar sensitivity to ultrasonography in diagnosing lymph nodes. According to PET/CT, more patients were staged rT3-4 or rN + , and the rN-stage was more accurate . Accordingly, the contours of local recurrence were more precise when aided by PET/CT plus MRI. Patients staged by PET/CT plus MRI had a higher 3-year OS than patients staged by MRI alone . Conclusion: PET/CT more accurately detected and staged recurrence of nasopharyngeal carcinoma and accordingly complemented MRI, providing benefit in contouring and OS.收起

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