获取途径

作者

Zilin Meng Chunbo Liu Chao Chen Fanglin Di Shuping Zhang Xue Liang Meng Li

作者单位

¹Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University, Jinan, Shandong 250117, China ²These authors contributed equally to this work. ³Department of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong 250014, China ⁵School of Public Health, Shandong First Medical University, Jinan, Shandong 250117, China ⁴Medical Science and Technology Innovation Center, Shandong First Medical University, Jinan, Shandong 250117, China

刊名

Brain Research

年份

2022

页码

148133

ISSN

0006-8993

关键词

posthemorrhagic hydrocephalus ferroptosis choroid plexus

分类号

616.8

摘要

Posthemorrhagic hydrocephalus is a common neurological disease characterized by the disordered secretion of cerebrospinal fluid from the choroid plexus, ventricular dilation, and increased intracranial pressure after hemorrhage. Although these pathological processes are well established, the effective biomarkers for the diagnosis of PHH are still limited, largely because the underlying mechanisms—including cell death in the choroid plexus—are not well defined. Ferroptosis, a newly recognized ty...更多

Posthemorrhagic hydrocephalus is a common neurological disease characterized by the disordered secretion of cerebrospinal fluid from the choroid plexus, ventricular dilation, and increased intracranial pressure after hemorrhage. Although these pathological processes are well established, the effective biomarkers for the diagnosis of PHH are still limited, largely because the underlying mechanisms—including cell death in the choroid plexus—are not well defined. Ferroptosis, a newly recognized type of programmed cell death, has been found to play a key role in a variety of pathologic conditions and diseases, including Parkinson’s and Alzheimer’s diseases. However, whether ferroptosis is induced in PHH is still unknown. In the current study, a rat model of PHH was established to investigate the induction of ferroptosis in PHH. Along with defects in memory and cognition, we observed that rats with experimentally induced PHH also demonstrated lipid peroxidation , as well as a significant increase and a significant decrease in two ferroptosis-specific genes, ACSL4 and SLC7A11, respectively. Thus, ferroptosis may serve as an auxiliary indicator for the diagnosis of PHH.收起

学科

【SCI学科】NEUROSCIENCES 【ESI学科】NEUROSCIENCE & BEHAVIOR

影响因子

2018年:2.929;2017年:3.125;2016年:2.746;2015年:2.561;2014年:2.843

文献类型

期刊