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作者

F Comina

作者单位

¹山东第一医科大学附属济南人民医院检验科 山东 济南 27110 ³中日友好医院检验科 北京 10000 ²山东第一医科大学附属济南人民医院儿科 山东 济南 27110

刊名

Progress in Modern Biomedicine

年份

2022

卷号

Vol.22 No.16

页码

3126-3131

ISSN

1673-6273

关键词

Children Inflammation Mycoplasma pneumoniae pneumonia Prognosis 儿童 炎症 肺炎支原体肺炎 预后 CCL5 Gal-3 SP-D

摘要

Objective: To investigate the relationship between serum surfactant protein-D , galectin-3 and C-C motif chemokine ligand 5 levels and inflammatory factors and poor prognosis in children with mycoplasma pneumoniae pneumonia . Methods: A total of 165 children with MPP who were admitted to our hospital from January 2020 to January 2021 were selected as the MPP group, and 54 healthy children were selected as the control group. Serum SP-D, Gal-3, CCL5, interleukin-6 and IL-8 levels were measured...更多

Objective: To investigate the relationship between serum surfactant protein-D , galectin-3 and C-C motif chemokine ligand 5 levels and inflammatory factors and poor prognosis in children with mycoplasma pneumoniae pneumonia . Methods: A total of 165 children with MPP who were admitted to our hospital from January 2020 to January 2021 were selected as the MPP group, and 54 healthy children were selected as the control group. Serum SP-D, Gal-3, CCL5, interleukin-6 and IL-8 levels were measured by ELISA, and serum tumor necrosis factor-α level was measured by radioimmunoassay. Pearson/Spearman coefficients were used to analyze the correlation between serum SP-D, Gal-3 and CCL5 levels and IL-6, IL-8, and TNF-α levels in children with MPP. The influencing factors of poor prognosis in children with MPP were analyzed by multivariate Logistic regression, and receiver operating characteristic curve was used to analyze the predictive value of serum SP-D, Gal-3 and CCL5 levels on poor prognosis in children with MPP. Results: Compared with the control group, serum SP-D, Gal-3, CCL5, IL-6, IL-8 and TNF-α levels in children with MPP group increased . The serum SP-D, Gal-3 and CCL5 levels in children with MPP were positively correlated with IL-6, IL-8 and TNF-α levels . Serum SP-D, Gal-3, CCL5, IL-6 and TNF-α high levels, the lesion type was large flaky shadow and long heat range were the risk factors for poor prognosis in children with MPP . The area under the curve of serum SP-D, Gal-3 and CCL5 in predicting the poor prognosis of children with MPP was 0.926, which was significantly greater than 0.842, 0.794 and 0.771 predicted by the three indexes alone. Conclusion: The elevated levels of serum SP-D, Gal-3 and CCL5 in children with MPP are closely related to inflammatory factors and poor prognosis, which can be used as a predictor of poor prognosis in children with MPP.收起

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