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作者

Yan Bai Liwei Gao Xianfeng Wang Lili Zhong Jingfeng Li Shenggang Ding Yuejie Zheng Jun Liu Yuxia Cui Lina Wang Mingfeng Han Xinping Jiang Min Jiang Junhua Li Ning Chen Yunxiao Shang Hourong Zhou Yi Xu Gen Lu Xing Chen Jizhi Xu Qihong Fan Yu Tang Jiang Wu Cen Li Xiaoxiang Yang Chunxi Chen Yonghong Yang Gary Wing-Kin Wong Adong Shen Tianyou Wang Runming Jin Baoping Xu Kunling Shen

作者单位

Affiliations ¹ Pediatric Department Union Hospital Tongji Medical College Huazhong University of Science and Technology Hubei China. ² China National Clinical Research Center for Respiratory Diseases Department of Respiratory Medicine Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China. ³ Department of Pediatrics Shenzhen Third People's Hospital Second Affiliated Hospital of Southern University of Science and Technology Shenzhen China. ⁴ Children's medical center of Hunan Provincial People's Hospital Hunan China. ⁵ Taihe Hospital Shiyan Hubei China. ⁶ Department of Pediatrics the First Affiliated Hospital of Anhui Medical University Hefei Anhui China. ⁷ Department of Respiratory Medicine Shenzhen Children's Hospital Shenzhen China. ⁸ Department of Pediatrics Guizhou Provincial People's Hospital Guizhou China. ⁹ Department of Respiratory medicine The Second People's Hospital of Fuyang Anhui China. ¹⁰ Department of Pediatrics the People Hospital of Bozhou Anhui China. ¹¹ Loudi Central Hospital Loudi City, Hunan China. ¹² Department of Pediatrics the First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China. ¹³ Department of Pediatrics Xiangyang Central Hospital Xiangyang Hubei China. ¹⁴ Department of Pediatric Shengjing Hospital of China Medical University Liaoning China. ¹⁵ Department of General Practice Guizhou Provincial People's Hospital Office of Academic Research Jiangjunshan Hospital Guiyang, Guizhou China. ¹⁶ Department of Pediatric Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China. ¹⁷ Department of Pediatrics Shangdong Provincial Hospital Affiliated to Shandong First Medical University Shangdong China. ¹⁸ Changsha Maternal and Child Health Hospital Changsha Hunan China. ¹⁹ Department of Pediatrics Jingzhou First People's Hospital Jingzhou Hubei China. ²⁰ Children's Hospital Affiliated to Zhengzhou University Zhengzhou Henan China. ²¹ Huangshi Maternity and Child Health Care Hospital Huangshi Hubei China. ²² Guizhou Provincial People's Hospital Guizhou China. ²³ Department of Pediatrics the Maternal Child Health Hospital of Guangxi Zhuang Autonomous Region Nanning Guangxi China. ²⁴ Xishui People's Hospital Huanggang Hubei China. ²⁵ Beijing Pediatric Reasearch Institute Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China. ²⁶ Chinese University of Hong Kong Shatin Hong Kong China. ²⁷ Beijing Key Laboratory of Pediatric Respiratory Infectious Diseases Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China. ²⁸ Hematologic Oncology Center Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China.

刊名

Pediatric investigation

年份

2021

卷号

Vol.5 No.3

页码

203-210

ISSN

2574-2272

关键词

COVID‐19 Children SARS‐CoV‐2.

摘要

Importance: The Coronavirus disease 2019 global pandemic poses a considerable challenge for pediatricians. Objective: This study aimed to identify the epidemiological characteristics and clinical features of pediatric patients with COVID-19 in China. Methods: This multicenter retrospective study included pediatric patients from 46 hospitals in China, covering 12 provinces and two municipalities. Epidemiological, demographic, clinical, laboratory, treatment, and outcome data were analyzed. Resul...更多

Importance: The Coronavirus disease 2019 global pandemic poses a considerable challenge for pediatricians. Objective: This study aimed to identify the epidemiological characteristics and clinical features of pediatric patients with COVID-19 in China. Methods: This multicenter retrospective study included pediatric patients from 46 hospitals in China, covering 12 provinces and two municipalities. Epidemiological, demographic, clinical, laboratory, treatment, and outcome data were analyzed. Results: In total, 211 pediatric patients with COVID-19 were included in this study. The median age was 7.0 years . Approximately 16.3% of the patients exhibited asymptomatic infections, 23.0% had upper respiratory tract infections, and 60.7% had pneumonia, including two with severe pneumonia and one with critical illness. Approximately 78.7% of the pediatric patients occurred in familial clusters. The most three common symptoms or signs at onset in children with COVID-19 were fever , cough , and pharyngeal congestion . Only 17.6% of the patients presented with decreased lymphocyte count, whereas 13.6% had increased lymphocyte count. Among the patients with pneumonia who exhibited abnormal chest computed tomography findings, 18.2% of the patients had no other symptoms. Generally, the chest radiographs showed abnormalities that affected both lungs ; ground-glass opacity was the most common manifestation. The cure and improvement rates were 86.7% and 13.3% , respectively. Only one patient with an underlying condition received invasive mechanical ventilation; none of the patients died. Interpretation: Similar to adults, children of all age groups are susceptible to COVID-19. Fortunately, most pediatric patients have mild symptoms or remain asymptomatic, despite the high incidence of pneumonia. Decreased proportions of white blood cells and lymphocytes are less frequent in children than in adults.收起

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