Biological characteristics of γδT cells and application in tumor immunotherapy

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作者单位: Affiliations ¹ Department of Laboratory Medicine, Second Affiliated Hospital of Shandong First Medical University, Tai'an, China. ² Department of Laboratory Medicine, Tai'an Tumor Prevention and Treatment Hospital, Tai'an, China. ³ Department of Laboratory Medicine, Second Hospital of Traditional Chinese Medicine, Tai'an, China. ⁴ Department of Laboratory Medicine, The Affiliated Tai'an City Central Hospital of Qingdao University, Tai'an, China.

摘要: Human γδT cells are a special immune cell type which exist in small quantities in the body, do not require processing and presentation for antigen recognition, and have non-major histocompatibility complex -restricted immune response. They play an important role in the body's anti-tumor, anti-infection, immune regulation, immune surveillance and maintenance of immune tolerance. This article reviews the generation and development of human γδT cells, genetic characteristics, classification, recogn...更多; Human γδT cells are a special immune cell type which exist in small quantities in the body, do not require processing and presentation for antigen recognition, and have non-major histocompatibility complex -restricted immune response. They play an important role in the body's anti-tumor, anti-infection, immune regulation, immune surveillance and maintenance of immune tolerance. This article reviews the generation and development of human γδT cells, genetic characteristics, classification, recognition and role of antigens, and research progress in tumor immunotherapy.收起

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