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作者

Chao Liu Min Zhang Xinlong Yan Yanli Ni Yandong Gong Cong Wang Xiaoling Zhang Lingfei Wan Hui Yang Chen Ge Yunqiao Li Wenxue Zou Rui Huang Xiaohui Li Bing Sun Bing Liu Jinbo Yue Jinming Yu

作者单位

Affiliations ¹ Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China. ² Research Unit of Radiation Oncology, Chinese Academy of Medical Sciences, Jinan 250117, China. ³ Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China. ⁴ Faculty of Environmental and Life Sciences, Beijing University of Technology, Beijing 100124, China. ⁵ State Key Laboratory of Experimental Hematology, Senior Department of Hematology, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China. ⁶ Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China. ⁷ Department of Radiation Oncology, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100071, China.

刊名

Science advances

年份

2023

卷号

Vol.9 No.4

页码

eadd8977

ISSN

2375-2548

摘要

Cervical squamous cell carcinoma is a prototypical human cancer with well-characterized pathological stages of initiation and progression. However, high-resolution knowledge of the transcriptional programs underlying each stage of CESC is lacking, and important questions remain. We performed single-cell RNA sequencing of 76,911 individual cells from 13 samples of human cervical tissues at various stages of malignancy, illuminating the transcriptional tumorigenic trajectory of cervical epithelia...更多

Cervical squamous cell carcinoma is a prototypical human cancer with well-characterized pathological stages of initiation and progression. However, high-resolution knowledge of the transcriptional programs underlying each stage of CESC is lacking, and important questions remain. We performed single-cell RNA sequencing of 76,911 individual cells from 13 samples of human cervical tissues at various stages of malignancy, illuminating the transcriptional tumorigenic trajectory of cervical epithelial cells and revealing key factors involved in CESC initiation and progression. In addition, we found significant correlations between the abundance of specific myeloid, lymphoid, and endothelial cell populations and the progression of CESC, which were also associated with patients' prognosis. Last, we demonstrated the tumor-promoting function of matrix cancer-associated fibroblasts via the NRG1-ERBB3 pathway in CESC. This study provides a valuable resource and deeper insights into CESC initiation and progression, which is helpful in refining CESC diagnosis and for the design of optimal treatment strategies.收起

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