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作者

Ying-Hui, Jin Qing-Yuan, Zhan Zhi-Yong, Peng Xue-Qun, Ren Xun-Tao, Yin Lin, Cai Yu-Feng, Yuan Ji-Rong, Yue Xiao-Chun, Zhang Qi-Wen, Yang Jian-Guang, Ji Jian, Xia Yi-Rong, Li Fu-Xiang, Zhou Ya-Dong, Gao Zhui, Yu Feng, Xu Ming-Li, Tu Li-Ming, Tan Min, Yang Fang, Chen Xiao-Ju, Zhang Mei, Zeng Yu, Zhu Xin-Can, Liu Jian, Yang Dong-Chi, Zhao Yu-Feng, Ding Ning, Hou Fu-Bing, Wang Hao, Chen Yong-Gang, Zhang Wei, Li Wen, Chen Yue-Xian, Shi Xiu-Zhi, Yang Xue-Jun, Wang Yan-Jun, Zhong Ming-Juan, Zhao Bing-Hui, Li Lin-Lu, Ma Hao, Zi Na, Wang Yun-Yun, Wang Shao-Fu, Yu Lu-Yao, Li Qiao, Huang Hong, Weng Xiang-Ying, Ren Li-Sha, Luo Man-Ru, Fan Di, Huang Hong-Yang, Xue Lin-Xin, Yu Jin-Ping, Gao Tong, Deng Xian-Tao, Zeng Hong-Jun, Li Zhen-Shun, Cheng Xiao-Mei, Yao Xing-Huan, Wang

作者单位

^anDepartment of Respiratory and Critical Care Medicine, Kaifeng Central Hospital, Kaifeng, Henan, 475000, China ^aeDepartment of Infectious Disease, West China Second Hospital, Sichuan University, Chengdu, 610041, China ^fEmergency Center, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China ^kDepartment of Hematology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China ^amSchool of Nursing, Peking University, Beijing, 100191, China ^atDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada ⁱDepartment of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China ^apICU Center, Second Xiangya Hospital, Central South University, Changsha, 410008, China ^ahDepartment of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China ^tDepartment of Periodical Press, West China Hospital, Sichuan University, Chengdu, 610041, China ^aiDepartment of Pharmacy, Shandong Provincial Hospital, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, 250021, China ^afDepartment of Cardiology, First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450000, China ^uDepartment of Clinical Laboratory, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College, Chinese Academy of Medical Sciences (CAMS), Beijing, 100730, China ^hDepartment of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China ^gDepartment of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China ^rNational Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China ^aaDepartment of Intensive Care Unit, Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China ^yDepartment of Respiratory and Critical Care Medicine, Suizhou Central Hospital, Hubei University of Medicine, Suizhou, Hubei, 441300, China ^sDepartment of Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China ³Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China ^abDepartment of Internal Medicine, Zhengzhou University Hospital, Zhengzhou, 450001, China ^pInstitutes of Evidence-Based Medicine and Knowledge Translation, Henan University, Kaifeng, Henan, 475000, China ^zDepartment of Clinic Pharmacy, Second People's Hospital of Huaihua City, Huaihua, Hunan, 418000, China ^qDepartment of Medical Imaging, Guizhou Provincial People's Hospital, Guiyang, 550002, China ^wDepartment of Critical Care Medicine, Renmin Hospital, Wuhan University, Wuhan, 430060, China ²Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China ^arSchool of Nursing, Shanxi Medical University, Taiyuan, 030001, China ¹Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China ^ajLaboratory of Integrated Acupuncture and Drugs, Nanjing University of Chinese Medicine, Nanjing, 210023, China ^aoDepartment of Emergency, Beijing Electric Power Hospital, Beijing, 100073, China ^agDepartment of Cardiology, First People's Hospital of Yichang, People's Hospital of China, Three Gorges University, Yichang, Hubei, 443000, China ⁿDepartment of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, 10029, China ^eDepartment of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China ^lDepartment of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China ^xDepartment of Emergency Medicine, Chest Pain Center, Qilu Hospital, Shandong University, Jinan, 250002, China ^mNational Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, 10029, China ^asDepartment of Diagnostic Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China ^alDepartment of Radiology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China ^adDepartment of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, 201102, China ^jDepartment of Urology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China ^aqCollege of Nursing and Health, Henan Medical School, Henan University, Kaifeng, Henan, 475000, China ⁴Department of Hepatobiliary Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China ^vCenter for Primary Health Care Research, Lund University and Region Skåne, Malmö, 25002, Sweden ^akDepartment of Clinical Laboratory, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, 264000, China ^acDepartment of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital, Zhengzhou, 450003, China ^oLeishenshan Hospital in Wuhan, Wuhan, 430200, China

刊名

Medical Journal of Chinese People's Liberation Army

年份

2020

卷号

Vol.45 No.10

页码

1003-1031

ISSN

0577-7402

关键词

coronavirus disease 2019 severe acute respiratory syndrome coronavirus 2 infectious diseases clinical practice guidelines evidence-based medicine

摘要

The novel severe acute respiratory syndrome coronavirus 2 is the cause of a rapidly spreading illness, coronavirus disease 2019 , affecting more than seventeen million people around the world. Diagnosis and treatment guidelines for clinicians caring for patients are needed. In the early stage, we have issued 'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus infected pneumonia '; now there are many direct evidences emerged and may change some of previous recomm...更多

The novel severe acute respiratory syndrome coronavirus 2 is the cause of a rapidly spreading illness, coronavirus disease 2019 , affecting more than seventeen million people around the world. Diagnosis and treatment guidelines for clinicians caring for patients are needed. In the early stage, we have issued 'A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus infected pneumonia '; now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline. We formed a working group of clinical experts and methodologists. The steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas: chemoprophylaxis, diagnosis, treatments, and discharge management. We searched the literature for direct evidence on the management of COVID-19, and assessed its certainty generated recommendations using the Grading of Recommendations, Assessment, Development and Evaluation approach. Recommendations were either strong or weak, or in the form of ungraded consensus-based statement. Finally, we issued 34 statements. Among them, 6 were strong recommendations for, 14 were weak recommendations for, 3 were weak recommendations against and 11 were ungraded consensus-based statement. They covered topics of chemoprophylaxis [including agents and Traditional Chinese Medicine agents], diagnosis [including clinical manifestations, reverse transcription-polymerase chain reaction , respiratory tract specimens, IgM and IgG antibody tests, chest computed tomography, chest X-ray, and CT features of asymptomatic infections], treatments [including lopinavir-ritonavir, umifenovir, favipiravir, interferon, remdesivir, combination of antiviral drugs, hydroxychloroquine/chloroquine, interleukin-6 inhibitors, interleukin-1 inhibitors, glucocorticoid, Qingfei Paidu decoction, Lianhua Qingwen granules/capsules, convalescent plasma, lung transplantation, invasive or noninvasive ventilation, and extracorporeal membrane oxygenation ], and discharge management . We also created two figures of these recommendations for the implementation purpose. We hope these recommendations can help support healthcare workers caring for COVID-19 patients.收起

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