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作者

Xin Cao Hong-Guang Hu Min Shen Kai Deng Nan Wu

作者单位

Affiliations ¹ Department of Radiology, Huashan Hospital, Shanghai, China. ² Department of Radiology, The First Affiliated Hospital of Shandong First Medical University < Shandong Provincial Qianfoshan Hospital, Jinan, China.

刊名

Current medical imaging

年份

2022

ISSN

1573-4056

关键词

Ground-glass nodules Ki-67 Lung adenocarcinomas Spectral CT.

摘要

Objective We assessed the feasibility of spectral CT imaging for diagnosing lung adenocarcinomas manifesting as ground-glass nodules with varying Ki-67 expression. Methods Spectral CT parameters in 116 patients with lung adenocarcinomas manifesting as GGNs were analyzed. Cases were grouped into pre-invasive/minimally invasive adenocarcinoma and invasive adenocarcinoma groups. The Ki-67 labeling index was measured and compared between the two groups. Ki-67 LI was divided into three grades bas...更多

Objective We assessed the feasibility of spectral CT imaging for diagnosing lung adenocarcinomas manifesting as ground-glass nodules with varying Ki-67 expression. Methods Spectral CT parameters in 116 patients with lung adenocarcinomas manifesting as GGNs were analyzed. Cases were grouped into pre-invasive/minimally invasive adenocarcinoma and invasive adenocarcinoma groups. The Ki-67 labeling index was measured and compared between the two groups. Ki-67 LI was divided into three grades based on the number of positive-stained cells. Spectral CT parameters were compared among the three different grades. The correlation between quantitative spectral CT imaging parameters and Ki-67 LI was analyzed using Spearman correlation analysis. Results Ki-67 LI in the IA group was significantly higher than in the pre/MIA group . Grade 2 had higher diameter, WCL, and monochromatic CT values, and grade 1 had higher ICL and λHU. The WCL and monochromatic CT values were highly and positively correlated with Ki-67 LI. CT40keV had the highest correlation with Ki-67 LI, the diameter was moderately correlated with Ki-67 LI, and ICL and λHU were weakly correlated with Ki-67 LI. Conclusions Spectral CT, a noninvasive diagnostic method, is valuable for predicting Ki-67 expression higher in IA, thus allowing preoperative evaluation of lung adenocarcinomas manifesting as GGNs.收起

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