Deficiency of GDF-11 Accelerates TAC-Induced Heart Failure by Impairing Cardiac Angiogenesis

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作者: Jinyun Zhu Ning Zhang Yun Zhao Qi Liu Yingchao Wang Mingyao Chen Qunchao Ma Aiqiang Dong Yaping Wang Hong Yu

作者单位: ⁴Department of Cardiology, Affiliated Hangzhou First People’s Hospital, College of Medicine, Zhejiang University, Hangzhou, China ⁸Department of Cardiovascular Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China ⁵Department of Ultrasound, Second Affiliated Hospital of Shandong First Medical University, Taian, China ¹Department of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China ⁷Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China ⁶Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China ²Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, China ³Drs Zhu, Zhang, and Zhao contributed equally to this work.

摘要: The role of growth differentiation factor -11 in cardiac diseases has not been fully determined. Our study revealed that GDF-11 is not essential for myocardial development and physiological growth, whereas its absence exacerbates heart failure under pressure overload condition via impairing the responsive angiogenesis. GDF-11 induced VEGF expression in CMs by activating the Akt/mTOR pathway. The effect of endogenous GDF-11 on the heart belongs to local self-regulation of myocardial tissue, rathe...更多; The role of growth differentiation factor -11 in cardiac diseases has not been fully determined. Our study revealed that GDF-11 is not essential for myocardial development and physiological growth, whereas its absence exacerbates heart failure under pressure overload condition via impairing the responsive angiogenesis. GDF-11 induced VEGF expression in CMs by activating the Akt/mTOR pathway. The effect of endogenous GDF-11 on the heart belongs to local self-regulation of myocardial tissue, rather than a way of systemic regulation.收起

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