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作者

Yang Yang Jinyan Yuan Zhenzhong Liu Wenwen Cao Pei Liu

作者单位

¹Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Shandong First Medical University, Tai’an, China ³Department of Burn and Plastic Surgery, Qilu Hospital Affiliated to Shandong University, Jinan, China ²Department of Respiratory Medicine, The Second Affiliated Hospital of Shandong First Medical University, Tai’an, China

刊名

Frontiers in Oncology

年份

2022

卷号

Vol.12

页码

972550

ISSN

2234-943X

关键词

HJURP cholangiocarcinoma prognosis biomarker CCA subsets

摘要

BackgroundCholangiocarcinoma is the malignancy originating from the biliary epithelium, including intrahepatic , perihilar , and distal CCA. The prognosis of CCA is very poor, and the biomarkers of different CCA subsets should be investigated separately. Holliday junction recognition protein is a key component of the pre-nucleosomal complex, which is responsible for normal mitosis. The ectopic expression of HJURP has been reported in several cancers, but not CCA.Materials and methodsIn our st...更多

BackgroundCholangiocarcinoma is the malignancy originating from the biliary epithelium, including intrahepatic , perihilar , and distal CCA. The prognosis of CCA is very poor, and the biomarkers of different CCA subsets should be investigated separately. Holliday junction recognition protein is a key component of the pre-nucleosomal complex, which is responsible for normal mitosis. The ectopic expression of HJURP has been reported in several cancers, but not CCA.Materials and methodsIn our study, we investigated the expression of HJURP in 127 CCA patients which were composed of 32 iCCAs, 71 pCCAs, and 24 dCCAs with immunohistochemistry and divided these patients into subgroups with a low or high expression of HJURP. With chi-square test and univariate and multivariate analyses, we evaluated the clinical relevance and prognostic significance of HJURP in iCCAs, pCCAs, and dCCAs.ResultsHJURP was ectopically upregulated in CCAs compared with the para-tumor tissues based on TCGA and other mRNA-seq databases. A high expression of HJURP was correlated with low overall survival rates of iCCA and pCCA, but not in dCCA. Moreover, HJURP was an independent prognostic biomarker in both iCCA and pCCA. Patients with high HJURP were more likely to suffer CCA-related death after operation.ConclusionsHJURP was an independent prognostic biomarker in both iCCA and pCCA, but not in dCCA. Our results provide more evidence of the molecular features of different CCA subsets and suggest that patients with high HJURP are more high-risk, which can guide more precision follow-up and treatment of CCA.收起

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