Murine lung cDC1s inhibit memory Th2 cell generation by reducing CD62L memory precursors via IL-12

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作者: Jianguo Liu Linqing Du Shuying Yi Lina Li Yan Lin Yanan Bi Guangming Zhu Xiuli Jing Wengang Song Hua Tang

作者单位: Affiliations ¹ Department of Rheumatology and Autoimmunology, Shandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China. ² School of Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China. ³ Institute of infection and immunity, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.

关键词: Interleucina-12 Células Th2 Humanos Camundongos Animais Pulmão Memória Imunológica

摘要: GLO:1X5/01nov22:all15470-fig-0001.jpg PHOTO : 1 cDC1 depletion elevates memory potential of primed CD4+T cells to generate memory Th2 cells. Long-lived type 2 CD4 SP + sp T helper memory cells are critical for persistence and relapses of allergic asthma; however, their generation remains poorly understood.1 Type 1 and type 2 conventional dendritic cells play distinct roles in CD8 SP + sp T memory cell generation and Th2 functional polarization,2-4 and we wondered whether they could play a ro...更多; GLO:1X5/01nov22:all15470-fig-0001.jpg PHOTO : 1 cDC1 depletion elevates memory potential of primed CD4+T cells to generate memory Th2 cells. Long-lived type 2 CD4 SP + sp T helper memory cells are critical for persistence and relapses of allergic asthma; however, their generation remains poorly understood.1 Type 1 and type 2 conventional dendritic cells play distinct roles in CD8 SP + sp T memory cell generation and Th2 functional polarization,2-4 and we wondered whether they could play a role in fate decision of memory Th2 cells during allergen exposure. Murine lung cDC1s inhibit memory Th2 cell generation by reducing CD62L+ memory precursors via IL-12. [Extracted from the article]收起

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