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作者

Lulu Zhang Yi Lu Xiaoli Ma Yuanxin Xing Jinbo Sun Yanfei Jia

作者单位

³Department of Neurology, Jinan Central Hospital, Shandong University, Jinan, China ²Research Center of Basic Medicine, Jinan Central Hospital, Shandong University, Jinan, China ¹Research Center of Basic Medicine, Jinan Central Hospital, Shandong First Medical University, Jinan, China

刊名

Frontiers in Molecular Biosciences

年份

2022

卷号

Vol.9

页码

965924

ISSN

2296-889X

关键词

G-quadruplex p53 ferroptosis cancer biological activities

摘要

Ferroptosis is a novel form of regulated cell death trigged by various biological processes, and p53 is involved in different ferroptosis regulations and functions as a crucial regulator. Both DNA and RNA can fold into G-quadruplex in GC-rich regions and increasing shreds of evidence demonstrate that G-quadruplexes have been associated with some important cellular events. Investigation of G-quadruplexes is thus vital to revealing their biological functions. Specific G-quadruplexes are investigat...更多

Ferroptosis is a novel form of regulated cell death trigged by various biological processes, and p53 is involved in different ferroptosis regulations and functions as a crucial regulator. Both DNA and RNA can fold into G-quadruplex in GC-rich regions and increasing shreds of evidence demonstrate that G-quadruplexes have been associated with some important cellular events. Investigation of G-quadruplexes is thus vital to revealing their biological functions. Specific G-quadruplexes are investigated to discover new effective anticancer drugs. Multiple modulations have been discovered between the secondary structure G-quadruplex and p53, probably further influencing the ferroptosis in cancer. G-quadruplex binds to ferric iron-related structures directly and may affect the p53 pathways as well as ferroptosis in cancer. In addition, G-quadruplex also interacts with p53 indirectly, including iron-sulfur cluster metabolism, telomere homeostasis, lipid peroxidation, and glycolysis. In this review, we summarized the latent interplay between G-quadruplex and p53 which focused mainly on ferroptosis in cancer to provide the potential understanding and encourage future studies.收起

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