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作者

Xuepeng Zhang Lifan Zhang Canzheng Wei Liwei Feng Juqin Yang Geng Zhang Guoyan Lu Xiying Gui Yue Zhou Kaiying Yang Jiangyuan Zhou Xinle Zhou Ruoran Wang Siyuan Chen Yi Ji

作者单位

Affiliations ¹ Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, China. ² Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China. ³ Department of Critical Care Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, China. ⁴ West China School of Medicine, Sichuan University, Chengdu, China. ⁵ Department of Critical Care Medicine, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China. ⁶ Biobank, West China Hospital, Sichuan University, Chengdu, China. ⁷ Department of Pediatric Critical Care Medicine, West China Women's and Children's Hospital, Sichuan University, Chengdu, China. ⁸ Department of Critical Care Medicine, People's Hospital of Tibet Autonomous Region, Lhasa, China. ⁹ Department of Pediatric Critical Care Medicine, Sichuan Provincial Maternity and Child Health Care Hospital, Chengdu, China.

刊名

Frontiers in nutrition

年份

2022

卷号

Vol.9

页码

931599

ISSN

2296-861X

关键词

albumin children critical care mortality restricted cubic spline

摘要

Introduction: The detailed association between albumin levels and mortality has not been studied in critically ill children. The aim of this study was to reveal an association between albumin levels in detail and mortality in critically ill children. Materials and methods: We retrospectively collected data from children admitted to four pediatric intensive care units in China between January 2015 and October 2020. Restricted cubic spline curves based on logistic regression models were generated...更多

Introduction: The detailed association between albumin levels and mortality has not been studied in critically ill children. The aim of this study was to reveal an association between albumin levels in detail and mortality in critically ill children. Materials and methods: We retrospectively collected data from children admitted to four pediatric intensive care units in China between January 2015 and October 2020. Restricted cubic spline curves based on logistic regression models were generated to evaluate the detailed associations between serum albumin levels and PICU mortality. Threshold effect analysis was performed using two piecewise regression models. Results: The study included 9,123 children. The overall mortality was 5.3%. The detailed association between serum albumin levels and the risk of mortality followed a U-shape. The risk of mortality decreased with increasing serum albumin levels in children with serum albumin levels < 43.2 g/L and increased with increasing serum albumin levels in children with serum albumin levels ≥ 43.2 g/L. Conclusion: There was a U-shaped association between serum albumin levels and mortality in critically ill children in the PICU.收起

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