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作者

王金朝 许尚臣

作者单位

山东第一医科大学附属省立医院神经外科，山东 济南 山东第一医科大学附属省立医院神经外科，山东 济南

刊名

Advances in Clinical Medicine

年份

2023

卷号

Vol.13 No.4

页码

6406-6416

ISSN

2161-8712

关键词

低级别胶质瘤 层粘连蛋白基因家族 生物信息学 细胞外基质 Low-Grade Glioma Laminin Family Genes Bioinformatics Extracellular Matrix

摘要

To investigate the expression and prognostic value of laminin family genes in low-grade glioma, we conducted a bioinformatics data mining analysis. We obtained expression data and clinical infor-mation for low-grade glioma from various databases, validated the expression of different grades of glioma using R, calculated survival outcomes for low-grade glioma, and applied an ROC prediction model for validation. Furthermore, we analyzed gene variations and protein-protein interactions of laminin f...更多

To investigate the expression and prognostic value of laminin family genes in low-grade glioma, we conducted a bioinformatics data mining analysis. We obtained expression data and clinical infor-mation for low-grade glioma from various databases, validated the expression of different grades of glioma using R, calculated survival outcomes for low-grade glioma, and applied an ROC prediction model for validation. Furthermore, we analyzed gene variations and protein-protein interactions of laminin family genes in low-grade glioma using cBioPortal, String, GeneMANIA, and DAVID data-bases, and performed functional enrichment analysis. Our results showed that LAMA4, LAMA5, LAMB1, LAMB2, LAMB4, LAMC1, LAMC2, and LAMC3 were significantly oncogenic in low-grade glio-ma, closely associated with clinical WHO staging, and exhibited progressively increasing expression levels in grades 2 to 4. Conversely, LAMA3 was found to be a tumor suppressor, with expression lev-els decreasing with increasing WHO grade. Survival analysis indicated that all genes except LAMC2 were statistically significant in low-grade glioma. The TCGA database and cBioPortal analysis re-vealed relatively low mutation rates for these genes. Functional enrichment analysis revealed that the main cancer-related functions of laminin family genes involved extracellular matrix, cell adhe-sion, and cancer-related signaling. In conclusion, laminin family molecules may serve as potential targets for low-grade glioma grading and prognosis, providing a new perspective for research and personalized treatment of glioma.收起

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