Parietal Epithelial Cells and Glomerular Dis-eases

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关键词: 壁层上皮细胞新月体肾小球硬化信号通路信号分子 Parietal Epithelial Cells Crescents Glomerulosclerosis Signaling Pathway Signaling Molecules

摘要: Glomerular endothelial cells, mesangial cells, podocytes and parietal epithelial cells play an important role in the pathogenesis of glomerular disease as intrinsic cells of the glomerular. In recent years, with the deepening of the research on PECs, it has been found that PECs can be activated in normal physiological functions and pathological processes, and play an important role in the formation and progression of glomerular crescents and spherical sclerosis. In this review, we will review t...更多; Glomerular endothelial cells, mesangial cells, podocytes and parietal epithelial cells play an important role in the pathogenesis of glomerular disease as intrinsic cells of the glomerular. In recent years, with the deepening of the research on PECs, it has been found that PECs can be activated in normal physiological functions and pathological processes, and play an important role in the formation and progression of glomerular crescents and spherical sclerosis. In this review, we will review the role of PECs in maintaining normal physiological functions of glomerulus and in the occurrence and development of glomerular diseases as well as the related signaling pathways and molecules.收起

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