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作者

Qianqian Liu, Min Peng, Tiantian Yang, Guomin Si

作者单位

Affiliations ¹ School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China. ² Department of Chinese and Western Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

刊名

PloS one

年份

2023

卷号

Vol.18 No.11

页码

e0293832

ISSN

1932-6203

摘要

Purpose: Studying the effects of uric acid levels on cognitive function and quantifying the dose-response relationship. Methods: Based on PubMed and Embase search terms, we identified prospective cohort studies that included blood uric acid as a risk factor and cognitive impairment as a result up to September 2022. We extracted pooled relative risks and corresponding 95% confidence intervals . Results: Nine reports with median follow-up of 8.8-22 years were eligible for analyses. Compared with...更多

Purpose: Studying the effects of uric acid levels on cognitive function and quantifying the dose-response relationship. Methods: Based on PubMed and Embase search terms, we identified prospective cohort studies that included blood uric acid as a risk factor and cognitive impairment as a result up to September 2022. We extracted pooled relative risks and corresponding 95% confidence intervals . Results: Nine reports with median follow-up of 8.8-22 years were eligible for analyses. Compared with lowest category of blood uric acid concentration, the combined RR of cognitive impairment events in the highest classification was 0.81 . Dose-response analysis of eight reports showed that there was no evidence of a curvilinear relationship between blood uric acid levels and cognitive impairment . The summary RR of cognitive impairment for an increase of 1 mg/dL blood uric acid level was 0.98 . There was also a linear negative association between blood uric acid levels and cognitive impairment risk in the male subgroup analysis . Conclusion: Levels of blood uric acid are not related to risk of cognitive impairment. A subgroup analysis shows that the rise in blood uric acid levels in the male population is related to a decreased risk of cognitive impairment. These results need to be confirmed by further studies.收起

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