Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells

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作者: Chu-Xuan Liu Ying Gao Xiu-Fang Xu Xin Jin Yun Zhang Qian Xu Huan-Xin Ding Bing-Jun Li Fang-Ke Du Lin-Chuan ui Ming-Wei Zhong

作者单位: Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University；Department of General Surgery, Linyi People's Hospital；Department of Nursing, Huantai TCM Hospital；Center for Translational medical Research, The First Affiliated Hospital of Shandong First Medical University；Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University

关键词: Gastric cancer Ferroptosis Bile acids Chenodeoxycholic acid Farnesoid X receptor Glutathione

摘要: BACKGROUND Gastric cancer is associated with high mortality rates.Bile acids reflux is a well-known risk factor for GC, but the specific mechanism remains unclear.During GC development in both humans and animals, BAs serve as signaling molecules that induce metabolic reprogramming.This confers additional cancer phenotypes, including ferroptosis sensitivity.Ferroptosis is a novel mode of cell death characterized by lipid peroxidation that contributes universally to malignant progression.However...更多; BACKGROUND Gastric cancer is associated with high mortality rates.Bile acids reflux is a well-known risk factor for GC, but the specific mechanism remains unclear.During GC development in both humans and animals, BAs serve as signaling molecules that induce metabolic reprogramming.This confers additional cancer phenotypes, including ferroptosis sensitivity.Ferroptosis is a novel mode of cell death characterized by lipid peroxidation that contributes universally to malignant progression.However, it is not fully defined if BAs can influence GC progression by modulating ferroptosis.收起

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