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作者

Shishuo Li Xiaoqing Lu Qihao Chai Benzhao Huang Shimin Dai Peng Wang Jianing Liu Zhibo Zhao Xiao Li Bing Liu Kangqing Zuo Zhentao Man Ningbo Li Wei Li

作者单位

⁵School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong Province 250021, P. R. China ⁶Department of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji’nan, Shandong Province 250021, P. R. China ¹Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji’nan, Shandong Province 250021, P. R. China ⁷Shandong Institute of Endocrine and Metabolic Diseases, Endocrine and Metabolic Diseases Hospital of Shandong First Medical University, Ji’nan, Shandong Province 250062, P. R. China ³College of Sports Medicine and Rehabilitation, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong Province 250021, P. R. China ²Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong Province 250021, P. R. China ⁴Department of Orthopedic Surgery, The 903rd Hospital of PLA, Hangzhou, Zhejiang Province 310009, P. R. China

刊名

ACS Applied Materials & Interfaces

年份

2024

卷号

Vol.16 No.23

页码

29805-29822

ISSN

1944-8244

关键词

periprosthetic osteolysis Nb₂C MXene ROS-responsive signal pathway osteoclastogenesis osseointegration

摘要

Periprosthetic osteolysis induced by the ultrahigh-molecular-weight polyethylene wear particles is a major complication associated with the sustained service of artificial joint prostheses and often necessitates revision surgery. Therefore, a smart implant with direct prevention and repair abilities is urgently developed to avoid painful revision surgery. Herein, we fabricate a phosphatidylserine- and polyethylenimine-engineered niobium carbide MXenzyme-coated micro/nanostructured titanium imp...更多

Periprosthetic osteolysis induced by the ultrahigh-molecular-weight polyethylene wear particles is a major complication associated with the sustained service of artificial joint prostheses and often necessitates revision surgery. Therefore, a smart implant with direct prevention and repair abilities is urgently developed to avoid painful revision surgery. Herein, we fabricate a phosphatidylserine- and polyethylenimine-engineered niobium carbide MXenzyme-coated micro/nanostructured titanium implant that inhibits UHMWPE particle-induced periprosthetic osteolysis. The specific mechanism by which PPN@MNTi operates involves the bioresponsive release of nanosheets from the MNTi substrate within an osteolysis microenvironment, initiated by the cleavage of a thioketal–dopamine molecule sensitive to reactive oxygen species . Subsequently, functionalized NbC MXenzyme could target macrophages and escape from lysosomes, effectively scavenging intracellular ROS through its antioxidant nanozyme-mimicking activities. This further achieves the suppression of osteoclastogenesis by inhibiting NF-κB/MAPK and autophagy signaling pathways. Simultaneously, based on the synergistic effect of MXenzyme-integrated coatings and micro/nanostructured topography, the designed implant promotes the osteogenic differentiation of bone mesenchymal stem cells to regulate bone homeostasis, further achieving advanced osseointegration and alleviable periprosthetic osteolysis in vivo. This study provides a precise prevention and repair strategy of periprosthetic osteolysis, offering a paradigm for the development of smart orthopedic implants.收起

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期刊