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作者

Chi Zhang Xuezhen Zhao Xingqi Pan Gerili Zaya Bing Lyu Shaohua Li Jingguang Li Yunfeng Zhao Yongning Wu Dawei Chen

作者单位

⁶School of Public Health, Jinzhou Medical University, Jinzhou 121001, China ³C. Zhang and X. Zhao contributed equally to this work. ¹School of Food and Health, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China ⁵Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China ²NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (No. 2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100021, China ⁴School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China

刊名

Science of The Total Environment

年份

2024

卷号

Vol.941

页码

173511

ISSN

0048-9697

摘要

4-Hydroxychlorothalonil , the main metabolite of chlorothalonil and the most widely used fungicide, has been frequently detected in human samples during monitoring. 4-OH CHT may exhibit higher toxicity and persistence in the environment compared to its prototype. In this study, a total of 540 paired serum and breast milk samples from pregnant women in three provinces in China were monitored for contaminant residues. 4-OH CHT was analyzed in the samples using ultra high-performance liquid chromat...更多

4-Hydroxychlorothalonil , the main metabolite of chlorothalonil and the most widely used fungicide, has been frequently detected in human samples during monitoring. 4-OH CHT may exhibit higher toxicity and persistence in the environment compared to its prototype. In this study, a total of 540 paired serum and breast milk samples from pregnant women in three provinces in China were monitored for contaminant residues. 4-OH CHT was analyzed in the samples using ultra high-performance liquid chromatography - high-resolution mass spectrometry with a detection limit of 20 ng/L. The study investigated the effects of demographic factors, such as BMI, region of residence, and education level, on the levels of 4-OH CHT residues in serum and breast milk. Among the three provinces, the highest median concentration of 4-OH CHT in serum samples was observed in Hebei , while the highest median concentration of 4-OH CHT in breast milk samples was observed in Hubei and Guangdong . Multiple linear regression was used to investigate the significant positive correlation between 4-OH CHT in serum and breast milk after adjusting for personal characteristics. Based on this, the study further explored the influencing factors of transfer efficiencies in conjunction with the individual TEs and the personal characteristics of the participants. Our results demonstrated that the age of the volunteers and their exercise habits had an effect on TEs, but further studies are needed to determine whether exercise leads to an increase in TEs.收起

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