Research progress on post-translational RNA 5-methylcytosine methylation in tumors

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作者单位: ^bDepartment of Clinical Laboratory, Liaocheng People’s Hospital, Liaocheng People’s Hospital Affiliated to Shandong First Medical University, Liaocheng, 252000, China ^aDepartment of Central Laboratory, Liaocheng People ’s Hospital, Liaocheng People ’s Hospital Affiliated, Shandong First Medical University, Liaocheng, 252000, China

摘要: 5-methylcytosine is an important post-translationally modified base in RNA formed by cytosine methylation. As the development of methylation sequencing techniques, extensive mC modifications have been found in both coding and non-coding RNA. Incorporation of mC into RNA is regulated by methyltransferases, demethylases, and mC-binding proteins. mC incorporation regulates RNA stability, transport, translation, and pressure stress. Recent studies have revealed that mC incorporation into RNA is inv...更多; 5-methylcytosine is an important post-translationally modified base in RNA formed by cytosine methylation. As the development of methylation sequencing techniques, extensive mC modifications have been found in both coding and non-coding RNA. Incorporation of mC into RNA is regulated by methyltransferases, demethylases, and mC-binding proteins. mC incorporation regulates RNA stability, transport, translation, and pressure stress. Recent studies have revealed that mC incorporation into RNA is involved in the regulation of tumor pathogenesis, development, invasion, metastasis, and resistance. This article reviews mC-mediated regulatory mechanisms and functions, and research progress on mC-modified RNA functions in tumors, thus providing novel insights for developing innovative tumor diagnostic and therapeutic strategies.收起

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