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作者

Xiaoyun Wang, Xiaohua Ma, Jingyao Song, Bing Liu, Jiawei Wang

作者单位

Affiliations ¹ Nursing Department, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. ² Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. ³ Department of Ophthalmology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. ⁴ Department of Ophthalmology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. Electronic address: liub63@mail sysu.edu.cn. ⁵ Department of Ophthalmology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. Electronic address: jiaweieye@sdu.edu.cn.

刊名

Experimental eye research

年份

2024

卷号

Vol.242

页码

109878

ISSN

1096-0007

关键词

Anti-VEGF Aqueous humor Lipid Neovascular glaucoma.

摘要

The objective of this study was to examine the lipid spectrum of aqueous humor in patients with neovascular glaucoma secondary to proliferative diabetic retinopathy and to investigate the lipid alteration response to anti-vascular endothelial growth factor treatment. Lipidomic analysis using ultra-high performance liquid chromatography-tandem mass spectrometry was conducted to compare the lipid profiles of the AH in NVG patients with those of a control group. Lipid changes in the AH of NVG pa...更多

The objective of this study was to examine the lipid spectrum of aqueous humor in patients with neovascular glaucoma secondary to proliferative diabetic retinopathy and to investigate the lipid alteration response to anti-vascular endothelial growth factor treatment. Lipidomic analysis using ultra-high performance liquid chromatography-tandem mass spectrometry was conducted to compare the lipid profiles of the AH in NVG patients with those of a control group. Lipid changes in the AH of NVG patients before and after intravitreal conbercept injections were also evaluated. The identification of lipids showing differential expression was accomplished through both multivariate and univariate analyses. This study included 13 NVG patients and 20 control subjects. Based on LipidSearch software, 639 lipid species across 33 lipid classes were detected in the participants' AH. The combination of univariate and multivariate statistical analyses yielded 53 differentially expressed lipids . In addition, 9 lipids were found to be differentially expressed before and after the intravitreal conbercept injections in the NVG patients. Significant alterations in the metabolic pathways of glycerophospholipid and glycerolipid exhibited notable changes. Our results highlighted the lipid changes in patients' AH in relation to the progression of NVG, and indicated that the modified lipids could potentially be utilized as therapeutic targets for NVG.收起

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