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作者

Chunxue Fu, Hanrui Guo, Meiling Wang, Caiya Ni, Xiangwei Wu, Xueling Chen, Jun Hou, Lianghai Wang

作者单位

com. ⁵ Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China Department of Pathology, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. ⁴ Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, The First Affiliated Hospital/Shihezi University School of Medicine, Shihezi, Xinjiang, China. ² Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, The First Affiliated Hospital/Shihezi University School of Medicine, Shihezi, Xinjiang, China Department of Clinical Laboratory, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. ³ Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, The First Affiliated Hospital/Shihezi University School of Medicine, Shihezi, Xinjiang, China. Electronic address: lh_wang@shzu.edu.cn. NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, The First Affiliated Hospital/Shihezi University School of Medicine, Shihezi, Xinjiang, China. Electronic address: houjun229@16 Affiliations ¹ Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China

刊名

International immunopharmacology

年份

2024

卷号

Vol.143 Part 3

页码

113591

ISSN

1878-1705

关键词

CD8(+) T cells CXCL10 Cisplatin HCC Mn(2+) cGAS-STING.

摘要

Hepatocellular carcinoma is a major cause of cancer-related deaths worldwide. Chemotherapy using cisplatin, a drug that damages deoxyribonucleic acid , is not very effective in treating HCC due to its side effects and drug resistance. Manganese , a trace element, has been shown to enhance immune responses, but its ability to improve cisplatin-induced antitumor immunity in HCC remains unclear. The present study found that treatment with Mn in combination with cisplatin promoted cyclic GMP-AMP sy...更多

Hepatocellular carcinoma is a major cause of cancer-related deaths worldwide. Chemotherapy using cisplatin, a drug that damages deoxyribonucleic acid , is not very effective in treating HCC due to its side effects and drug resistance. Manganese , a trace element, has been shown to enhance immune responses, but its ability to improve cisplatin-induced antitumor immunity in HCC remains unclear. The present study found that treatment with Mn in combination with cisplatin promoted cyclic GMP-AMP synthase -stimulator of interferon genes signaling activation and C-X-C motif chemokine ligand 10 production in tumor and dendritic cells. CXCL10 is associated with CD8A levels, and its high expression is linked to better prognosis in patients with HCC. In addition, Mn and cisplatin co-treatment enhanced the recruitment of CD8 T cells through the CXCL10/CXCR3 axis. Similarly, in an orthotopic transplantation tumor model, STING activation, CD8 T cell infiltration, and tumor cell killing levels were higher in the combined treatment group. The above findings suggest that utilizing Mn in combination with cisplatin could be a potential treatment option for HCC.收起

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