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作者

Mikhail Kryuchkov, Jana Valnohova, Vladimir L Katanaev

作者单位

Affiliations ¹ Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Rue Michel Servet 1, CH-1211 Geneva, Switzerland. ² School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University (Shandong Academy of Medical Sciences), Tai'an 271016, China.

刊名

Biomolecules

年份

2024

卷号

Vol.14 No.11

页码

1388

ISSN

2218-273X

关键词

Turing dispersion relation order reaction rate reaction-diffusion.

摘要

Artificial bio-nanocoatings, primarily composed of proteins, offer a broad range of applications across various fields thanks to their unique properties. Proteins, as major components of these structures, enable a high degree of customization, such as mutations, conjugation with other molecules or nanoparticles, or the inclusion of an enzymatic activity. Their ability to self-assembly simplifies the production of bio-nanocoatings, making this process efficient and environment-friendly. Despite t...更多

Artificial bio-nanocoatings, primarily composed of proteins, offer a broad range of applications across various fields thanks to their unique properties. Proteins, as major components of these structures, enable a high degree of customization, such as mutations, conjugation with other molecules or nanoparticles, or the inclusion of an enzymatic activity. Their ability to self-assembly simplifies the production of bio-nanocoatings, making this process efficient and environment-friendly. Despite these advantages, a comprehensive understanding of the underlying self-assembly mechanism is lacking, and the reaction rates governing this process have not been characterized. In this article, we introduce a novel method to determine the key parameters describing the self-assembly mechanism of bio-nanostructures. For the first time, this approach enables an accurate calculation of the autocatalytic and self-inhibitory parameters controlling the process. Through mathematical modeling, our method enhances the understanding of how the protein-based nanocoatings form and opens new avenues for their application in nanotechnology and synthetic biology. Improved control over the self-assembly processes may enable the development of nanomaterials optimized for specific functions, such as drug delivery, biosensing, and bioactive surface fabrication.收起

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