获取途径

作者

Nannan Xu, Xiaoai Zhang, Hui Liu, Yintao Xu, Huixia Lu, Lianhui Zhao, Yishan He, Meiqi Zhang, Jingtao Zhang, Guangqian Si, Ziyi Wang, Muxin Chen, Yuchun Cai, Yi Zhang, Qiang Wang, Yuwan Hao, Yuanyuan Li, Zhengbin Zhou, Yunhai Guo, Caiyun Chang, Ming Liu, Chuanmin Ma, Yongbin Wang, Liqun Fang, Shizhu Li, Gang Wang, Qin Liu, Wei Liu

作者单位

Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Jinan, Shandong 250012, China Affiliations ¹ Department of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China. ² State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing 100071, China. ³ Institute of Bacterial Disease, Jinan Center for Disease Control and Prevention, Jinan, Shandong 250021, China. ⁴ Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China. ⁵ Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China State Key Laboratory for Innovation and Transformation of Luobing Theory, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China. ⁶ National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention, Chinese Center for Tropical Diseases Research, National Research Center for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, National Health Commission, WHO Collaborating Center for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai 20025, China. ⁷ Institute for Infectious Disease Control, Jinan Center for Disease Control and Prevention, Jinan, Shandong 250021, China. ⁸ Shandong Institute of Parasitic Disease, Shandong First Medical University (Shandong Academy of Medical Sciences), Jining, Shandong 272033, China. ⁹ National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention, Chinese Center for Tropical Diseases Research, National Research Center for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, National Health Commission, WHO Collaborating Center for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai 20025, China. Electronic address: lisz@chinacdc.cn. ¹⁰ Department of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China. Electronic address: wangg1975@hotmail.com. ¹¹ National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention, Chinese Center for Tropical Diseases Research, National Research Center for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, National Health Commission, WHO Collaborating Center for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai 20025, China. Electronic address: liuqin@nipd.chinacdc.cn. ¹² State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Science, Beijing 100071, China. Electronic address: lwbime@16 com.

刊名

The Journal of infection

年份

2024

卷号

Vol.89 No.5

页码

106290

ISSN

1532-2742

关键词

China Human infection Rodent Trypanosoma dionisii Trypanosomiasis.

摘要

Background: Trypanosomiasis continues to pose a global threat to human health, with human infection mainly caused by Trypanosoma brucei and Trypanosoma cruzi. Methods: We present a 30-year-old pregnant woman with persistent high fever from Shandong Province, China. High-throughput sequencing revealed the presence of Trypanosoma dionisii in blood. We conducted an analysis of the patient's clinical, epidemiological, and virological data. Results: The patients exhibited fever, shortness of breath, ...更多

Background: Trypanosomiasis continues to pose a global threat to human health, with human infection mainly caused by Trypanosoma brucei and Trypanosoma cruzi. Methods: We present a 30-year-old pregnant woman with persistent high fever from Shandong Province, China. High-throughput sequencing revealed the presence of Trypanosoma dionisii in blood. We conducted an analysis of the patient's clinical, epidemiological, and virological data. Results: The patients exhibited fever, shortness of breath, chest tightness, accompanied by change in liver function and inflammatory response. She made a full recovery without any long-term effects. T. dionisii was detected in blood collected 23 days after onset of illness. The 18S rRNA gene sequence showed close similarity to T. dionisii found in bats from Japan, while the gGAPDH gene was closely related to T. dionisii from bats in Mengyin County, Shandong Province. Phylogenetic analysis demonstrated the current T. dionisii belongs to clade B within its species group. Positive anti-Trypanosoma IgG antibody was detected from the patient on Day 23, 66 and 122 after disease onset, as well as the cord blood and serum from the newborn. Retrospective screening of wild small mammals captured from Shandong Province revealed a prevalence rate of 0.54% for T. dionisii; specifically among 0.81% of Apodemus agrarius, and 0.46% of Mus musculus. Conclusions: The confirmation of human infection with T. dionisii underscores its potential as a zoonotic pathogen, while the widespread presence of this parasite in rodent and bat species emphasizes the emerging threat it poses to human health.收起

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