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作者

Jin-Xin Zheng, Shen-Ning Lu, Qin Li, Yue-Jin Li, Jin-Bo Xue, Tegemeo Gavana, Prosper Chaki, Ning Xiao, Yeromin Mlacha, Duo-Quan Wang, Xiao-Nong Zhou

作者单位

One Health Center, Shanghai Jiao Tong University - The Edinburgh University, Shanghai, 200025, China National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Health Commission Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, 200025, China. Electronic address: zhouxn1@chinacdc.cn. One Health Center, Shanghai Jiao Tong University - The Edinburgh University, Shanghai, 200025, China. ² National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Health Commission Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, 200025, China. ³ Shandong Institute of Parasitic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, Jining, 272033, China. ⁴ Ifakara Health Institute, Dar es Salaam, Tanzania. ⁵ National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Health Commission Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, 200025, China. Electronic address: wangdq@nipd.chinacdc.cn. ⁶ School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China Affiliations ¹ School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

刊名

Public health

年份

2024

卷号

Vol.238

页码

124-130

ISSN

1476-5616

关键词

Climate predictors Machine learning Malaria Model interpretation XGBoost.

摘要

Objectives: Malaria remains a critical public health challenge, especially in regions like southeastern Tanzania. Understanding the intricate relationship between environmental factors and malaria incidence is essential for effective control and elimination strategies. Study design: Cohort study. Methods: This cohort study, conducted between Jan 2016 and October 2021 across three districts in southeastern Tanzania, utilized advanced machine learning techniques, specifically the Extreme Gradient ...更多

Objectives: Malaria remains a critical public health challenge, especially in regions like southeastern Tanzania. Understanding the intricate relationship between environmental factors and malaria incidence is essential for effective control and elimination strategies. Study design: Cohort study. Methods: This cohort study, conducted between Jan 2016 and October 2021 across three districts in southeastern Tanzania, utilized advanced machine learning techniques, specifically the Extreme Gradient Boosting model, to examine the impact of climate factors on malaria incidence. SHapley Additive exPlanations values were applied to interpret model predictions, highlighting the roles of normalized difference vegetation index , temperature, and rainfall in shaping malaria transmission dynamics. Results: Analysis revealed considerable heterogeneity in malaria incidence across southeastern Tanzania, with Kibiti experiencing the highest number of cases over the study period. Seasonal peaks corresponded with rainy periods, though incidence rates varied by district. Incorporating lagged climate variables and seasonal trends significantly improved forecast accuracy, with the one-month lag model achieving the lowest mean absolute error and root mean squared error . SHAP analysis identified seasonality , followed by lagged temperature , rainfall , and NDVI , as the most influential factors, reflecting the biological underpinnings of malaria transmission. Conclusions: This study demonstrates the utility of machine learning and explainable SHAP in malaria epidemiology, providing a data-driven framework to guide targeted, climate-informed malaria control strategies. By capturing seasonal and climate-linked risks, these methods hold promise for enhancing public health planning and adaptive response in malaria-endemic regions.收起

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