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作者

Xiaotan Ji Xudong Zhang Jie Zhang Shenna Niu Hui Cong Xiao Hong Chen Chuanqiang Qu

作者单位

⁶Department of Emergency Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China People’s Hospital, Jining, China ³Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China ¹Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, China ⁵Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China ⁴Department of Neurology, Zouping People’s Hospital, Binzhou, China ²Department of Neurology, Jining No.

刊名

Frontiers in Aging Neuroscience

年份

2024

卷号

Vol.16

关键词

trimethylamine N-oxide TMAO WMH CSVD MMP-9

摘要

BackgroundCerebral white matter hyperintensity is a pivotal imaging feature of cerebral small vessel disease , closely correlated with an elevated risk of ischemic stroke . Trimethylamine N-oxide , a metabolite of gut microbiota, is increasingly associated with IS and atherosclerosis. However, the intricate relationship between TMAO and WMH remains ambiguous. This study aimed to study the connection between plasma TMAO and WMH. Furthermore, it assessed the potential of TMAO as a risk evaluation...更多

BackgroundCerebral white matter hyperintensity is a pivotal imaging feature of cerebral small vessel disease , closely correlated with an elevated risk of ischemic stroke . Trimethylamine N-oxide , a metabolite of gut microbiota, is increasingly associated with IS and atherosclerosis. However, the intricate relationship between TMAO and WMH remains ambiguous. This study aimed to study the connection between plasma TMAO and WMH. Furthermore, it assessed the potential of TMAO as a risk evaluation instrument for WMH.MethodsIn this cross-sectional study, we categorized WMH into periventricular WMH and deep WMH , based on its locations. The severity of WMH was assessed and grouped according to the Fazekas scale. Plasma TMAO levels were quantitatively determined. We established the correlation between plasma TMAO levels and WMH severity using a Logistic regression model. Additionally, we employed ROC curves to evaluate the diagnostic efficacy of plasma TMAO concentration in distinguishing the severity of WMH.ResultsA higher plasma TMAO tertile was significantly linked to a higher Fazekas score, encompassing the overall score, P-WMH score, and D-WMH score (p 0.5, while the AUC for moderate WMH was0.5.ConclusionPlasma TMAO levels exhibited a significant correlation with both overall and region-specific WMH severity. Furthermore, the plasma TMAO levels displayed robust predictive capability for D-WMH.收起

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