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作者

Li, Wenying Chen, Kai Zhang, Jinping Wang, Xiaohong Xu, Guangyu Zhu, Yinghong Lv, Yan

作者单位

²Ctr Dis Control & Prevent LaiWu City, Laiwu, Shandong, Peoples R China. ¹Taishan Med Coll, LaiWu Affiliated Hosp, Peoples Hosp LaiWu City, Ctr Reprod Med,Dept Obstet & Gynecol, Tai An, Shandong, Peoples R China. ³Taishan Med Coll, LaiWu Affiliated Hosp, Dept Urol, Peoples Hosp LaiWu City, Tai An, Shandong, Peoples R China.

刊名

SCIENTIFIC REPORTS

年份

2019

卷号

Vol.9

ISSN

2045-2322

关键词

CORONARY-ARTERY-DISEASE ENDOTHELIAL DYSFUNCTION GENERAL-POPULATION METABOLIC SYNDROME HEART-DISEASE RISK MEN INFLAMMATION ATHEROSCLEROSIS BIOMARKER

摘要

Inflammation has been known to affect endothelial function and is involved in the progression of erectile dysfunction . Thus, our present study was conducted to investigate the association between inflammatory marker high-sensitivity C-reactive protein and ED in a Chinese male population. A total of 1515 participants with anthropometric measurements, serum analyses and hs-CRP values available were included in our cross-sectional study. Data involving socioeconomic and lifestyle factors were als...更多

Inflammation has been known to affect endothelial function and is involved in the progression of erectile dysfunction . Thus, our present study was conducted to investigate the association between inflammatory marker high-sensitivity C-reactive protein and ED in a Chinese male population. A total of 1515 participants with anthropometric measurements, serum analyses and hs-CRP values available were included in our cross-sectional study. Data involving socioeconomic and lifestyle factors were also collected. ED was assessed by the 5-item International Index Erectile Function , and hs-CRP levels were measured by the immunoturbidimetric assay. Logistic regression was applied to estimate the association between the serum hs-CRP and the risk of ED, and receiver operating characteristics curve analysis was performed to identify the predictive value of hs-CRP. Serum hs-CRP levels were significantly higher in ED patients, and increased progressively with the incremental severity of ED . In the multivariate-adjusted model, men in the highest quartile of hs-CRP level versus those in the lowest quartile had a 50% increased likelihood for ED . When subjects were stratified by age, the risk of ED was more prominently in the middle-aged and elderly men. Based on the ROC analysis, serum hs-CRP has a poor diagnostic value for ED with an AUC of 0.58 but has a good diagnostic performance for differentiating severe ED . Our study indicates that increased serum hs-CRP levels are associated with the severity of ED and an increased ED risk in a Chinese male population. These findings suggest that hs-CRP may be of value as an inflammatory marker for the assessment of ED risk and may play an important role in the etiology of ED.收起

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