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作者

Xi-Ran Hou, Zhen-Yu Yan, Shuang Liu, Na Gao, Jian Chen, Ya-Wen Wang, Liang Wang, Zhao Li, Xin-Ru Wang, Qiao-Feng Dong, Qiu-Yan Wang, Lin Sun, Yan-Ming Wang, Ji Ma, Ya-Jing Zhao, Zhi-Long Xu, Cong-Cong Cao, Jun Peng, Ming Hou, Xin-Guang Liu

作者单位

People's Hospital, Jining, China. ⁶ Department of Hematology, Shengli Oilfield Central Hospital, Dongying, China. ⁷ Department of Hematology, Qilu Hospital of Shandong University, Qingdao, China. ⁸ Department of Hematology, Liaocheng People's Hospital, Liaocheng, China. ⁹ Department of Hematology, Heze Municipal Hospital, Heze, China. ¹⁰ Department of Hematology, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, China. ¹¹ Department of Hematology, Central Hospital Affiliated to Shandong First Medical University, Jinan, China. ¹² Department of Hematology, Yantai Yuhuangding Hospital, Yantai, China. ¹³ Department of Hematology, Shandong First Medical University Affiliated Tumor Hospital, Jinan, China. ¹⁴ Department of Hematology, Lanling Hospital, Linyi, China. ¹⁵ Department of Hematology, Qilu Hospital of Shandong University Pingyi Hospital, Pingyi, China. Affiliations ¹ Department of Hematology, Cheeloo College of Medicine, Qilu Hospital of Shandong University, Jinan, China. ² Department of Hematology, North China University of Science and Technology Affiliated Hospital, Tangshan, China. ³ Department of Hematology, Tai'an Central Hospital, Tai'an, China. ⁴ Department of Hematology, Binzhou Medical University Hospital, Binzhou, China. ⁵ Department of Hematology, Jining No.

刊名

British journal of haematology

年份

2024

ISSN

1365-2141

关键词

ITP T2DM corticosteroids metformin sustained response.

摘要

Corticosteroids are the standard first-line treatment for primary immune thrombocytopenia , with a high initial response but unsatisfactory sustained response . Additionally, corticosteroids usually lead to hyperglycaemia especially in patients with pre-existing type 2 diabetes mellitus . Besides reducing the blood glucose levels, metformin was found to have immunomodulatory effects. We hereby conducted a multicentre propensity score matching analysis of corticosteroids plus metformin versus cor...更多

Corticosteroids are the standard first-line treatment for primary immune thrombocytopenia , with a high initial response but unsatisfactory sustained response . Additionally, corticosteroids usually lead to hyperglycaemia especially in patients with pre-existing type 2 diabetes mellitus . Besides reducing the blood glucose levels, metformin was found to have immunomodulatory effects. We hereby conducted a multicentre propensity score matching analysis of corticosteroids plus metformin versus corticosteroids for newly diagnosed ITP patients with pre-existing T2DM. After matching at a ratio of 1:1, there were 57 patients in each group. Baseline characteristics, comorbidities and other medications including concurrent hypoglycaemic medications were balanced between the two groups. No statistical difference was observed in the initial response rate at day 14. It was notable that patients in the metformin group had a significantly higher SR rate and longer duration of response compared to the non-metformin group. Metformin inclusion was associated with a higher incidence of stomach upset, which were generally tolerable. Our study provided evidence that the addition of metformin to corticosteroids might be a promising front-line treatment for newly diagnosed ITP patients with pre-existing T2DM.收起

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