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作者

Ming Xie, Xiandeng Li, Lun Chen, Yufeng Zhang, Long Chen, Haibing Hua, Jia Qi

作者单位

International Centre for Genetic Engineering and Biotechnology, Taizhou, Jiangsu 225300, China. ⁶ Department of Gastroenterology, Jiangyin Hospital of Traditional Chinese Medicine, Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangyin, Jiangsu 214499, China. Electronic address: jiangy002@njucm.edu.cn. ⁷ Department of Pharmacy, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China. Electronic address: qijia@xinhuamed.com.cn. Department of Pharmacy, Jiangyin Hospital of Traditional Chinese Medicine, Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangyin, Jiangsu 214499, China. ² Department of Pharmacy, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China Department of Pulmonary and Critical Care Medicine, Jiangyin Hospital of Traditional Chinese Medicine, Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangyin, Jiangsu 214499, China. ⁵ Institute of Chinese Medicine of Taizhou China Medical City, Taizhou, Jiangsu 225316, China Affiliations ¹ Department of Pharmacy, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China College of Pharmacy, Chongqing Medical University, Chongqing 400016, China. ³ Department of Pharmacy, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China. ⁴ Department of Vascular Surgery, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, Shangdong 271000, China Postdoctoral Workstation, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shangdong 250117, China

刊名

Life sciences

年份

2024

页码

123319

ISSN

1879-0631

关键词

Adventitial fibroblast Crosstalk Vascular endothelial cells Vascular remodeling Vascular smooth muscle cells.

摘要

Pathological vascular remodeling is characterized by structural and functional alterations in the vascular wall resulting from injury, which significantly contribute to the development of cardiovascular diseases . The vascular wall consists primarily of endothelial cells , vascular smooth muscle cells , and adventitial fibroblasts , whose interactions are crucial for both the formation of the vascular system and the maintenance of mature blood vessels. Disruptions in the communication between t...更多

Pathological vascular remodeling is characterized by structural and functional alterations in the vascular wall resulting from injury, which significantly contribute to the development of cardiovascular diseases . The vascular wall consists primarily of endothelial cells , vascular smooth muscle cells , and adventitial fibroblasts , whose interactions are crucial for both the formation of the vascular system and the maintenance of mature blood vessels. Disruptions in the communication between these cell types have been implicated in the progression of VR. This review examines the complex interactions between ECs, VSMCs, and AFs in the context of CVD development, emphasizing a relatively underexplored yet potentially critical mechanism. This interaction framework likely extends to the broader cellular dialogue in the pathogenesis of CVDs, suggesting novel therapeutic strategies for intervention.收起

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