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作者

Yi Dong, Lin Song, Tingting Hou, Yuanjing Li, Yongxiang Wang, Yifeng Du, Chengxuan Qiu

作者单位

Affiliations ¹ Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China. ² The Swedish School of Sport and Health Sciences, GIH, Stockholm, Sweden., Stockholm, Sweden. ³ Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.

刊名

Alzheimer's & dementia : the journal of the Alzheimer's Association

年份

2024

卷号

Vol.20 Suppl 2

页码

e088199

ISSN

1552-5279

摘要

Background: Plasma neurofilament light has emerged as a promising biomarker to track neurodegeneration in Alzheimer's disease and other brain degenerative disorders. We sought to characterize brain structures and white matter lesions associated with plasma NfL among dementia-free older adults, while taking into account demographic factors and genetic susceptibility . Method: This population-based cross-sectional study included 844 non-demented older adults , derived from participants in the ba...更多

Background: Plasma neurofilament light has emerged as a promising biomarker to track neurodegeneration in Alzheimer's disease and other brain degenerative disorders. We sought to characterize brain structures and white matter lesions associated with plasma NfL among dementia-free older adults, while taking into account demographic factors and genetic susceptibility . Method: This population-based cross-sectional study included 844 non-demented older adults , derived from participants in the baseline assessments of the Multimodal INterventions to delay Dementia and disability in rural China study who had plasma NfL measured on the SIMOA platform in 2018 and undertook structural brain magnetic resonance imaging scan on a 3T scanner in 2018-2020. Structural brain measures were assessed using the Computational Anatomy Toolbox on the platform of MATLAB. Data were analysed using the multivariable linear regression models. Result: Per 1-SD increase in log-transformed NfL concentration was significantly associated with multivariable-adjusted β-coefficient of 0.09 for white matter hyperintensity volume, 0.09 for periventricular WMH volume, -2.71 for grey matter volume, -0.03 for entorhinal cortex volume, -0.04 for parahippocampal volume, -0.22 for AD-signature volume, and -0.02 for AD-signature cortical thickness. The associations of plasma NfL concentration with the MRI markers of neurodegeneration were statistically evident mainly among males or APOE ε4 allele carriers . Conclusion: Brain structures associated with increased plasma NfL in older adults are characterized by reduced grey matter volume, entorhinal cortex volume, parahippocampal volume, and AD-signature volume, especially among men or carriers of the APOE ε4 allele.收起

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