[A Review of progresses in research on delayed resistance to EGFR-TKI by Traditional Chinese medicine via inhibiting cancer stem cells properties]

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作者单位: Affiliations ¹ Basic Teaching and Research Office of Traditional Chinese Medicine, College of Integrated Traditional Chinese and Western Medicine, Jining Medical University, Jining 272067, China. ² Department of Chest Radiotherapy, Shandong First Medical University Affiliated Cancer Hospital, Jinan 250117, China. ³ Radioimmunoassay and Molecular Imaging Laboratory, Shandong First Medical University Affiliated Cancer Hospital, Jinan 250117, China. ⁴ Department of Internal Medicine, Shandong First Medical University Affiliated Cancer Hospital, Jinan 250117, China. ⁵ Department of Integrated Traditional Chinese and Western Medicine, Shandong First Medical University Affiliated Cancer Hospital, Jinan 250117, China. *Corresponding author, E-mail: linjiamao_@12 com.

刊名: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

摘要: It has been popular and challenging to undertake researches on the delay of acquired resistance of epidermal growth factor receptor tyrosine kinase inhibitors . As key cells for tumor initiation, cancer stem cells play an important role in the process of resistance to EGFR-TKI. Although preliminary studies found that traditional Chinese medicine could inhibit CSC properties and delay EGFR-TKI resistance, the specific molecular mechanism remains unclear. By summarizing the empirical syndrome tr...更多; It has been popular and challenging to undertake researches on the delay of acquired resistance of epidermal growth factor receptor tyrosine kinase inhibitors . As key cells for tumor initiation, cancer stem cells play an important role in the process of resistance to EGFR-TKI. Although preliminary studies found that traditional Chinese medicine could inhibit CSC properties and delay EGFR-TKI resistance, the specific molecular mechanism remains unclear. By summarizing the empirical syndrome treatment of EGFR-TKI resistance via TCM and combining recent researches on TCM intervention in CSC to delay EGFR-TKI resistance, this review discussed the potential molecular pathways and mechanisms of deceleration in resistance to EGFR-TKI by TCM via inhibiting CSC characteristics, in order to expand the research ideas of TCM in combination with targeted therapy.收起

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